Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action
Diabetic nephropathy (DN) is one of the most common and intractable microvascular complications of diabetes worldwide, serving as the main cause of terminal renal disease. Due to the lack of early specific symptoms and diagnostic markers, DN severely threatens the sufferer’s life. MicroRNA-192 (miR-...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1179161/full |
| _version_ | 1827925611501322240 |
|---|---|
| author | Xiaoqing Wan Jian Liao Hongting Lai Shilong Zhang Jianling Cui Chunyan Chen |
| author_facet | Xiaoqing Wan Jian Liao Hongting Lai Shilong Zhang Jianling Cui Chunyan Chen |
| author_sort | Xiaoqing Wan |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is one of the most common and intractable microvascular complications of diabetes worldwide, serving as the main cause of terminal renal disease. Due to the lack of early specific symptoms and diagnostic markers, DN severely threatens the sufferer’s life. MicroRNA-192 (miR-192) was early identified in human renal cortical tissue and stored and excreted in urine as microvesicles. MiR-192 was found to be involved in the development of DN. For the first time, the present review summarized all the current evidence on the topic of the roles of miR-192 in DN. Finally, 28 studies (ten clinical trials and eighteen experimental studies) were eligible for thorough reviewing. Most of the clinical trials (7/10, 70%) indicated miR-192 might be a protective factor for DN development and progression, while the majority of experimental studies (14/18, 78%) suggested miR-192 might be a pathogenic factor for DN. Mechanistically, miR-192 interacts with various direct targeted proteins (i.e., ZEB1, ZEB2, SIP1, GLP1R, and Egr1) and signaling cascades (i.e., SMAD/TGF-β and PTEN/PI3K/AKT), together contribute to the pathogenesis of DN through epithelial-to-mesenchymal transition (EMT), extracellular matrix deposition, and fibrosis formation. The current review highlights the dual role of miR-192 in the development of DN. Low serum miR-192 expression could be applied for the early prediction of DN (the early stage of DN), while the high miR-192 level in renal tissues and urine may imply the progression of DN (the late stage of DN). Further investigations are still warranted to illustrate this inconsistent phenomenon, which may facilitate promoting the therapeutic applications of miR-192 in predicting and treating DN. |
| first_indexed | 2024-03-13T05:26:34Z |
| format | Article |
| id | doaj.art-88953dbf064e4253aa953426d296ad67 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T05:26:34Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-88953dbf064e4253aa953426d296ad672023-06-15T05:36:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-06-011410.3389/fendo.2023.11791611179161Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of actionXiaoqing Wan0Jian Liao1Hongting Lai2Shilong Zhang3Jianling Cui4Chunyan Chen5Department of Nephrology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, ChinaDepartment of Nephrology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, ChinaClinical Medical College, Tianjin Medical University, Tianjin, ChinaClinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, ChinaDepartment of Nephrology, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, ChinaDiabetic nephropathy (DN) is one of the most common and intractable microvascular complications of diabetes worldwide, serving as the main cause of terminal renal disease. Due to the lack of early specific symptoms and diagnostic markers, DN severely threatens the sufferer’s life. MicroRNA-192 (miR-192) was early identified in human renal cortical tissue and stored and excreted in urine as microvesicles. MiR-192 was found to be involved in the development of DN. For the first time, the present review summarized all the current evidence on the topic of the roles of miR-192 in DN. Finally, 28 studies (ten clinical trials and eighteen experimental studies) were eligible for thorough reviewing. Most of the clinical trials (7/10, 70%) indicated miR-192 might be a protective factor for DN development and progression, while the majority of experimental studies (14/18, 78%) suggested miR-192 might be a pathogenic factor for DN. Mechanistically, miR-192 interacts with various direct targeted proteins (i.e., ZEB1, ZEB2, SIP1, GLP1R, and Egr1) and signaling cascades (i.e., SMAD/TGF-β and PTEN/PI3K/AKT), together contribute to the pathogenesis of DN through epithelial-to-mesenchymal transition (EMT), extracellular matrix deposition, and fibrosis formation. The current review highlights the dual role of miR-192 in the development of DN. Low serum miR-192 expression could be applied for the early prediction of DN (the early stage of DN), while the high miR-192 level in renal tissues and urine may imply the progression of DN (the late stage of DN). Further investigations are still warranted to illustrate this inconsistent phenomenon, which may facilitate promoting the therapeutic applications of miR-192 in predicting and treating DN.https://www.frontiersin.org/articles/10.3389/fendo.2023.1179161/fullMicroRNA-192diabetic nephropahybiomarkerZeb1mechanism |
| spellingShingle | Xiaoqing Wan Jian Liao Hongting Lai Shilong Zhang Jianling Cui Chunyan Chen Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action Frontiers in Endocrinology MicroRNA-192 diabetic nephropahy biomarker Zeb1 mechanism |
| title | Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action |
| title_full | Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action |
| title_fullStr | Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action |
| title_full_unstemmed | Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action |
| title_short | Roles of microRNA-192 in diabetic nephropathy: the clinical applications and mechanisms of action |
| title_sort | roles of microrna 192 in diabetic nephropathy the clinical applications and mechanisms of action |
| topic | MicroRNA-192 diabetic nephropahy biomarker Zeb1 mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1179161/full |
| work_keys_str_mv | AT xiaoqingwan rolesofmicrorna192indiabeticnephropathytheclinicalapplicationsandmechanismsofaction AT jianliao rolesofmicrorna192indiabeticnephropathytheclinicalapplicationsandmechanismsofaction AT hongtinglai rolesofmicrorna192indiabeticnephropathytheclinicalapplicationsandmechanismsofaction AT shilongzhang rolesofmicrorna192indiabeticnephropathytheclinicalapplicationsandmechanismsofaction AT jianlingcui rolesofmicrorna192indiabeticnephropathytheclinicalapplicationsandmechanismsofaction AT chunyanchen rolesofmicrorna192indiabeticnephropathytheclinicalapplicationsandmechanismsofaction |