Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the Literature
A 57-year-old man presented with a pigmented papule, 0.4 cm in diameter, on the left lower eyelid. Skin biopsy revealed a basal cell carcinoma, which was excised through a wide excision followed by a full-thickness skin graft (FTSG). Two weeks after the surgery, an erythematous nodule developed in t...
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2023-01-01
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| Series: | Archives of Plastic Surgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1988-2869 |
| _version_ | 1828035892381483008 |
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| author | Jeong Ho Kim Sang-Hoon Lee Seung-Phil Hong Jiye Kim Sug Won Kim |
| author_facet | Jeong Ho Kim Sang-Hoon Lee Seung-Phil Hong Jiye Kim Sug Won Kim |
| author_sort | Jeong Ho Kim |
| collection | DOAJ |
| description | A 57-year-old man presented with a pigmented papule, 0.4 cm in diameter, on the left lower eyelid. Skin biopsy revealed a basal cell carcinoma, which was excised through a wide excision followed by a full-thickness skin graft (FTSG). Two weeks after the surgery, an erythematous nodule developed in the lower margin of the graft recipient site. The nodule size increased rapidly over 2 weeks, becoming dome-shaped with a central hyperkeratotic plug. A diagnosis of keratoacanthoma (KA) was made, and surgical excision was performed. Histological findings revealed a large, well-differentiated squamous tumor with a central keratin-filled crater and buttress. The human papilloma virus (HPV) genotyping results were negative. Risk factors for KA include trauma, old age, exposure to ultraviolet (UV) radiation, immunosuppression, and HPV infection. KA has most often been reported to develop at the donor site. Although the pathogenesis of KA is unclear, trauma is believed to act as a second insult to a preceding oncogenic insult, such as exposure to UV radiation, resulting in a koebnerization. Herein, we report a case of solitary KA at a FTSG recipient site. This report presents information that may provide guidance during dermatologic surgeries. |
| first_indexed | 2024-04-10T15:52:58Z |
| format | Article |
| id | doaj.art-88962d2d515f4e86aeebe2d2f66f362d |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-10T15:52:58Z |
| publishDate | 2023-01-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-88962d2d515f4e86aeebe2d2f66f362d2023-02-11T00:01:43ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712023-01-01500105906210.1055/a-1988-2869Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the LiteratureJeong Ho Kim0Sang-Hoon Lee1Seung-Phil Hong2Jiye Kim3Sug Won Kim4Department of Plastic and Reconstructive Surgery, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaDepartment of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaDepartment of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaDepartment of Plastic and Reconstructive Surgery, Yonsei University Wonju College of Medicine, Wonju, Republic of KoreaA 57-year-old man presented with a pigmented papule, 0.4 cm in diameter, on the left lower eyelid. Skin biopsy revealed a basal cell carcinoma, which was excised through a wide excision followed by a full-thickness skin graft (FTSG). Two weeks after the surgery, an erythematous nodule developed in the lower margin of the graft recipient site. The nodule size increased rapidly over 2 weeks, becoming dome-shaped with a central hyperkeratotic plug. A diagnosis of keratoacanthoma (KA) was made, and surgical excision was performed. Histological findings revealed a large, well-differentiated squamous tumor with a central keratin-filled crater and buttress. The human papilloma virus (HPV) genotyping results were negative. Risk factors for KA include trauma, old age, exposure to ultraviolet (UV) radiation, immunosuppression, and HPV infection. KA has most often been reported to develop at the donor site. Although the pathogenesis of KA is unclear, trauma is believed to act as a second insult to a preceding oncogenic insult, such as exposure to UV radiation, resulting in a koebnerization. Herein, we report a case of solitary KA at a FTSG recipient site. This report presents information that may provide guidance during dermatologic surgeries.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1988-2869keratoacanthomakoebnerizationfull-thickness skin graft |
| spellingShingle | Jeong Ho Kim Sang-Hoon Lee Seung-Phil Hong Jiye Kim Sug Won Kim Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the Literature Archives of Plastic Surgery keratoacanthoma koebnerization full-thickness skin graft |
| title | Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the Literature |
| title_full | Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the Literature |
| title_fullStr | Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the Literature |
| title_full_unstemmed | Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the Literature |
| title_short | Solitary Keratoacanthoma at the Recipient Site of a Full-Thickness Skin Graft: A Case Report and Review of the Literature |
| title_sort | solitary keratoacanthoma at the recipient site of a full thickness skin graft a case report and review of the literature |
| topic | keratoacanthoma koebnerization full-thickness skin graft |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1988-2869 |
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