Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review
Obstructive sleep apnea (OSA) is a prevalent, underdiagnosed disease and is considered an independent risk factor for cardiovascular disease. The exact mechanism of cardiovascular complications (CVC) development as a complication of OSA is not entirely understood. Oxidative stress is suspected to be...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/9/11/3734 |
| _version_ | 1797547281384210432 |
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| author | Piotr Fiedorczuk Adam Stróżyński Ewa Olszewska |
| author_facet | Piotr Fiedorczuk Adam Stróżyński Ewa Olszewska |
| author_sort | Piotr Fiedorczuk |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a prevalent, underdiagnosed disease and is considered an independent risk factor for cardiovascular disease. The exact mechanism of cardiovascular complications (CVC) development as a complication of OSA is not entirely understood. Oxidative stress is suspected to be the essential factor in initiating various comorbidities in OSA. Biomarkers of nonenzymatic lipid and protein peroxidation, DNA repair and antioxidant capabilities measured in serum, plasma and urine are frequently used to assess the presence of oxidative stress. We conducted a systematic review and quality assessment of available observational analytic studies to determine whether there is an association between oxidative stress and OSA in patients with prevalent CV disease compared to (a) patients with prevalent CV disease but no OSA, (b) patients with prevalent CV disease and less severe OSA and (c) patients with OSA and no overt CV disease. This systematic review demonstrated that, while oxidative stress is associated with OSA, there was no clear difference in the severity of oxidative stress between OSA patients with or without cardiovascular complications. |
| first_indexed | 2024-03-10T14:41:06Z |
| format | Article |
| id | doaj.art-8896354f7af84735af6acd57fb047d5f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:41:06Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8896354f7af84735af6acd57fb047d5f2023-11-20T21:46:07ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01911373410.3390/jcm9113734Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic ReviewPiotr Fiedorczuk0Adam Stróżyński1Ewa Olszewska2Doctoral School of the Medical University of Bialystok, 15-328 Białystok, PolandMedical University of Bialystok, 15-328 Białystok, PolandDepartment of Otolaryngology Medical University of Bialystok, 15-328 Białystok, PolandObstructive sleep apnea (OSA) is a prevalent, underdiagnosed disease and is considered an independent risk factor for cardiovascular disease. The exact mechanism of cardiovascular complications (CVC) development as a complication of OSA is not entirely understood. Oxidative stress is suspected to be the essential factor in initiating various comorbidities in OSA. Biomarkers of nonenzymatic lipid and protein peroxidation, DNA repair and antioxidant capabilities measured in serum, plasma and urine are frequently used to assess the presence of oxidative stress. We conducted a systematic review and quality assessment of available observational analytic studies to determine whether there is an association between oxidative stress and OSA in patients with prevalent CV disease compared to (a) patients with prevalent CV disease but no OSA, (b) patients with prevalent CV disease and less severe OSA and (c) patients with OSA and no overt CV disease. This systematic review demonstrated that, while oxidative stress is associated with OSA, there was no clear difference in the severity of oxidative stress between OSA patients with or without cardiovascular complications.https://www.mdpi.com/2077-0383/9/11/3734Sleep apneaoxidative stresscardiovascular disease |
| spellingShingle | Piotr Fiedorczuk Adam Stróżyński Ewa Olszewska Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review Journal of Clinical Medicine Sleep apnea oxidative stress cardiovascular disease |
| title | Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review |
| title_full | Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review |
| title_fullStr | Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review |
| title_full_unstemmed | Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review |
| title_short | Is the Oxidative Stress in Obstructive Sleep Apnea Associated with Cardiovascular Complications?—Systematic Review |
| title_sort | is the oxidative stress in obstructive sleep apnea associated with cardiovascular complications systematic review |
| topic | Sleep apnea oxidative stress cardiovascular disease |
| url | https://www.mdpi.com/2077-0383/9/11/3734 |
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