REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES
Children and teenagers aged 10-17 years old with juvenile arthritis (n=99), with reactive arthritis (n=21), with systemic sclerosis (n=16), with systemic lupus erythematosus (n=14) and conditionally healthy (n=32) are investigated. It’s revealed by the method of flow cytometry that quantity of regul...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-08-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/701 |
| _version_ | 1826534268376973312 |
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| author | I. A. Pashnina |
| author_facet | I. A. Pashnina |
| author_sort | I. A. Pashnina |
| collection | DOAJ |
| description | Children and teenagers aged 10-17 years old with juvenile arthritis (n=99), with reactive arthritis (n=21), with systemic sclerosis (n=16), with systemic lupus erythematosus (n=14) and conditionally healthy (n=32) are investigated. It’s revealed by the method of flow cytometry that quantity of regulatory T-cells (CD3+CD4+CD25+CD127low/neg) in children with juvenile arthritis, with reactive arthritis and with systemicsclerosis was lower than in the control group. The amount of Treg in children with systemic lupus erythematosus was the same to the control level. The decrease of Treg number in most of investigated groups indicates that these cells are involved in the pathogenesis of an autoimmune diseases in children. It’s remaining unknown what’s the reason of normal Treg content in patients with systemic lupus erythematosus in contrast with other autoimmune diseases. There were positive correlation between the percentage of Treg and the amount ofdamaged joints in children with reactive arthritis and negative correlation between the amount of Treg and SLEDAI in children with systemic lupus erythematosus. The significant correlations between the numbers of CD3+CD25+, CD3+CD4+CD25+ and Treg were revealed, so there isn’t any reasonability of estimation of CD3+ and CD4+cells which are expressed CD25 as separate parameters. |
| first_indexed | 2024-03-08T05:49:51Z |
| format | Article |
| id | doaj.art-88993cd43eb243efa99e4872a933ac28 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:20:19Z |
| publishDate | 2014-08-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-88993cd43eb243efa99e4872a933ac282025-03-11T17:59:05ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-08-0116435336010.15789/1563-0625-2014-4-353-360698REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASESI. A. Pashnina0Regional Children's Clinical Hospital №1, Yekaterinburg Institute of Immunology and Physiology, Urals Branch of the Russian Academy of Science, YekaterinburgChildren and teenagers aged 10-17 years old with juvenile arthritis (n=99), with reactive arthritis (n=21), with systemic sclerosis (n=16), with systemic lupus erythematosus (n=14) and conditionally healthy (n=32) are investigated. It’s revealed by the method of flow cytometry that quantity of regulatory T-cells (CD3+CD4+CD25+CD127low/neg) in children with juvenile arthritis, with reactive arthritis and with systemicsclerosis was lower than in the control group. The amount of Treg in children with systemic lupus erythematosus was the same to the control level. The decrease of Treg number in most of investigated groups indicates that these cells are involved in the pathogenesis of an autoimmune diseases in children. It’s remaining unknown what’s the reason of normal Treg content in patients with systemic lupus erythematosus in contrast with other autoimmune diseases. There were positive correlation between the percentage of Treg and the amount ofdamaged joints in children with reactive arthritis and negative correlation between the amount of Treg and SLEDAI in children with systemic lupus erythematosus. The significant correlations between the numbers of CD3+CD25+, CD3+CD4+CD25+ and Treg were revealed, so there isn’t any reasonability of estimation of CD3+ and CD4+cells which are expressed CD25 as separate parameters.https://www.mimmun.ru/mimmun/article/view/701regulatory t-cellsjuvenile arthritisautoimmune diseaseschildren |
| spellingShingle | I. A. Pashnina REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES Медицинская иммунология regulatory t-cells juvenile arthritis autoimmune diseases children |
| title | REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES |
| title_full | REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES |
| title_fullStr | REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES |
| title_full_unstemmed | REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES |
| title_short | REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES |
| title_sort | regulatory t cells in children with autoimmune diseases |
| topic | regulatory t-cells juvenile arthritis autoimmune diseases children |
| url | https://www.mimmun.ru/mimmun/article/view/701 |
| work_keys_str_mv | AT iapashnina regulatorytcellsinchildrenwithautoimmunediseases |