Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint
Abstract Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring. Here, we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers includi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | npj Flexible Electronics |
| Online Access: | https://doi.org/10.1038/s41528-022-00192-6 |
| _version_ | 1811287387825766400 |
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| author | Xuecheng He Chuan Fan Yong Luo Tailin Xu Xueji Zhang |
| author_facet | Xuecheng He Chuan Fan Yong Luo Tailin Xu Xueji Zhang |
| author_sort | Xuecheng He |
| collection | DOAJ |
| description | Abstract Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring. Here, we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers including urea, lactate, and pH in sweat. A miniature, thin plasmonic metasurface with homogeneous mushroom-shaped hot spots and high surface-enhanced Raman scattering (SERS) activity is designed and integrated into a microfluidics platform. Compared to conventional wearable SERS platforms with the risk of mixed effect between new and old sweat, the microfluidic SERS system allows sweat administration in a controllable and high temporal-resolution fashion, providing refreshable SERS analysis. We use a portable and customized Raman analyzer with a friendly human-machine interface for portable recognition of the spectroscopic signatures of sweat biomarkers. This study integrates epidermal microfluidics with portable SERS molecular recognition, presenting a controllable, handy, and dynamical biofluid sensing system for personalized medicine. |
| first_indexed | 2024-04-13T03:17:39Z |
| format | Article |
| id | doaj.art-889942e36694405cb401bd57a5841e81 |
| institution | Directory Open Access Journal |
| issn | 2397-4621 |
| language | English |
| last_indexed | 2024-04-13T03:17:39Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Flexible Electronics |
| spelling | doaj.art-889942e36694405cb401bd57a5841e812022-12-22T03:04:52ZengNature Portfolionpj Flexible Electronics2397-46212022-07-016111010.1038/s41528-022-00192-6Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprintXuecheng He0Chuan Fan1Yong Luo2Tailin Xu3Xueji Zhang4School of Biomedical Engineering, Health Science Center, Shenzhen UniversitySchool of Biomedical Engineering, Health Science Center, Shenzhen UniversitySchool of Biomedical Engineering, Health Science Center, Shenzhen UniversitySchool of Biomedical Engineering, Health Science Center, Shenzhen UniversitySchool of Biomedical Engineering, Health Science Center, Shenzhen UniversityAbstract Wearable sweat sensors with various sensing systems can provide noninvasive medical diagnostics and healthcare monitoring. Here, we demonstrate a wearable microfluidic nanoplasmonic sensor capable of refreshable and portable recognition fingerprint information of targeted biomarkers including urea, lactate, and pH in sweat. A miniature, thin plasmonic metasurface with homogeneous mushroom-shaped hot spots and high surface-enhanced Raman scattering (SERS) activity is designed and integrated into a microfluidics platform. Compared to conventional wearable SERS platforms with the risk of mixed effect between new and old sweat, the microfluidic SERS system allows sweat administration in a controllable and high temporal-resolution fashion, providing refreshable SERS analysis. We use a portable and customized Raman analyzer with a friendly human-machine interface for portable recognition of the spectroscopic signatures of sweat biomarkers. This study integrates epidermal microfluidics with portable SERS molecular recognition, presenting a controllable, handy, and dynamical biofluid sensing system for personalized medicine.https://doi.org/10.1038/s41528-022-00192-6 |
| spellingShingle | Xuecheng He Chuan Fan Yong Luo Tailin Xu Xueji Zhang Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint npj Flexible Electronics |
| title | Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint |
| title_full | Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint |
| title_fullStr | Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint |
| title_full_unstemmed | Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint |
| title_short | Flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint |
| title_sort | flexible microfluidic nanoplasmonic sensors for refreshable and portable recognition of sweat biochemical fingerprint |
| url | https://doi.org/10.1038/s41528-022-00192-6 |
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