Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context
Abstract Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to efficiently treat diseases. Promising features of EVs include their innate therapeutic properties and ability to be engineered as targeted drug delivery systems. However, regulation of EV uptake is one chal...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-022-02806-2 |
| _version_ | 1819025984524910592 |
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| author | Abazar Esmaeili Mauro Alini Mohamadreza Baghaban Eslaminejad Samaneh Hosseini |
| author_facet | Abazar Esmaeili Mauro Alini Mohamadreza Baghaban Eslaminejad Samaneh Hosseini |
| author_sort | Abazar Esmaeili |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to efficiently treat diseases. Promising features of EVs include their innate therapeutic properties and ability to be engineered as targeted drug delivery systems. However, regulation of EV uptake is one challenge of EV therapy that must be overcome to achieve an efficient therapeutic outcome. Numerous efforts to improve the factors that affect EV uptake include the selection of a cell source, cell cultivation procedure, extraction and purification methods, storage, and administration routes. Limitations of rapid clearance, targeted delivery, and off-targeting of EVs are current challenges that must be circumvented. EV engineering can potentially overcome these limitations and provide an ideal therapeutic use for EVs. In this paper, we intend to discuss traditional strategies and their limitations, and then review recent advances in EV engineering that can be used to customize and control EV uptake for future clinical applications. |
| first_indexed | 2024-12-21T05:19:22Z |
| format | Article |
| id | doaj.art-889a2a53c28846b3ae45695d08f0b99a |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-21T05:19:22Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-889a2a53c28846b3ae45695d08f0b99a2022-12-21T19:14:51ZengBMCStem Cell Research & Therapy1757-65122022-03-0113111610.1186/s13287-022-02806-2Engineering strategies for customizing extracellular vesicle uptake in a therapeutic contextAbazar Esmaeili0Mauro Alini1Mohamadreza Baghaban Eslaminejad2Samaneh Hosseini3Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECRAO Research Institute DavosDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECRDepartment of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECRAbstract Extracellular vesicles (EVs) are advanced therapeutic strategies that can be used to efficiently treat diseases. Promising features of EVs include their innate therapeutic properties and ability to be engineered as targeted drug delivery systems. However, regulation of EV uptake is one challenge of EV therapy that must be overcome to achieve an efficient therapeutic outcome. Numerous efforts to improve the factors that affect EV uptake include the selection of a cell source, cell cultivation procedure, extraction and purification methods, storage, and administration routes. Limitations of rapid clearance, targeted delivery, and off-targeting of EVs are current challenges that must be circumvented. EV engineering can potentially overcome these limitations and provide an ideal therapeutic use for EVs. In this paper, we intend to discuss traditional strategies and their limitations, and then review recent advances in EV engineering that can be used to customize and control EV uptake for future clinical applications.https://doi.org/10.1186/s13287-022-02806-2Extracellular vesicle engineeringEV-targetingCustomizing EV uptake |
| spellingShingle | Abazar Esmaeili Mauro Alini Mohamadreza Baghaban Eslaminejad Samaneh Hosseini Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context Stem Cell Research & Therapy Extracellular vesicle engineering EV-targeting Customizing EV uptake |
| title | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
| title_full | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
| title_fullStr | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
| title_full_unstemmed | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
| title_short | Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
| title_sort | engineering strategies for customizing extracellular vesicle uptake in a therapeutic context |
| topic | Extracellular vesicle engineering EV-targeting Customizing EV uptake |
| url | https://doi.org/10.1186/s13287-022-02806-2 |
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