Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion
AIM:To evaluate the long-term efficacy and safety of retinal photocoagulation combined with intravitreal injection of Ranibizumab(IVR)and simple Ranibizumab in the treatment of branch retinal vein occlusion secondary macular edema(BRVO-ME).METHODS: The literatures related to randomized controlled cl...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2021-01-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2021/1/202101019.pdf |
| _version_ | 1818342922457710592 |
|---|---|
| author | Xiang-Rui Wu Feng-Ming Liang Shuai Song |
| author_facet | Xiang-Rui Wu Feng-Ming Liang Shuai Song |
| author_sort | Xiang-Rui Wu |
| collection | DOAJ |
| description | AIM:To evaluate the long-term efficacy and safety of retinal photocoagulation combined with intravitreal injection of Ranibizumab(IVR)and simple Ranibizumab in the treatment of branch retinal vein occlusion secondary macular edema(BRVO-ME).METHODS: The literatures related to randomized controlled clinical studies on the treatment of BRVO-ME with laser and Ranibizumab in Embase, The Cochrane Library, PubMed, China National Knowledge Infrastructure(CNKI), Wanfang Database and China Science and Technology Journal Database(VIP)were systematically retrieved, and the risk assessment was carried out and data indicators were extracted for the included studies. RevMan 5.3 software was used for data analysis and funnel plot was used to evaluate publication bias.RESULTS: Totally 7 studies were included, with 641 eyes. There was no significant difference in the best corrected visual acuity(BCVA)between the laser combined with Ranibizumab group and the simple Ranibizumab group at 12mo \ and 24mo \ after treatment. There was no significant difference in central foveal thickness between the two groups at 12mo \ and 24mo \. There were no statistically significant differences in the injection times of Ranibizumab and the incidence of final adverse events between the two groups at 12mo and 24mo after treatment.CONCLUSION: Compared with the treatment of BRVO-ME with simple Ranibizumab, there was no significant difference in the long-term efficacy of vision and central foveal thickness for the laser combined with Ranibizumab, and there was no significant difference in the injection times and safety of Ranibizumab. |
| first_indexed | 2024-12-13T16:22:23Z |
| format | Article |
| id | doaj.art-889a9704b118444f81e381f7c7b8f269 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-12-13T16:22:23Z |
| publishDate | 2021-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-889a9704b118444f81e381f7c7b8f2692022-12-21T23:38:41ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232021-01-01211929810.3980/j.issn.1672-5123.2021.1.19202101019Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusionXiang-Rui Wu0Feng-Ming Liang1Shuai Song2First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, ChinaAIM:To evaluate the long-term efficacy and safety of retinal photocoagulation combined with intravitreal injection of Ranibizumab(IVR)and simple Ranibizumab in the treatment of branch retinal vein occlusion secondary macular edema(BRVO-ME).METHODS: The literatures related to randomized controlled clinical studies on the treatment of BRVO-ME with laser and Ranibizumab in Embase, The Cochrane Library, PubMed, China National Knowledge Infrastructure(CNKI), Wanfang Database and China Science and Technology Journal Database(VIP)were systematically retrieved, and the risk assessment was carried out and data indicators were extracted for the included studies. RevMan 5.3 software was used for data analysis and funnel plot was used to evaluate publication bias.RESULTS: Totally 7 studies were included, with 641 eyes. There was no significant difference in the best corrected visual acuity(BCVA)between the laser combined with Ranibizumab group and the simple Ranibizumab group at 12mo \ and 24mo \ after treatment. There was no significant difference in central foveal thickness between the two groups at 12mo \ and 24mo \. There were no statistically significant differences in the injection times of Ranibizumab and the incidence of final adverse events between the two groups at 12mo and 24mo after treatment.CONCLUSION: Compared with the treatment of BRVO-ME with simple Ranibizumab, there was no significant difference in the long-term efficacy of vision and central foveal thickness for the laser combined with Ranibizumab, and there was no significant difference in the injection times and safety of Ranibizumab.http://ies.ijo.cn/cn_publish/2021/1/202101019.pdfretinal laser photocoagulationranibizumabanti-vegf therapymacular edema secondary to branch retinal vein occlusionmeta-analysislong-term efficacysafety |
| spellingShingle | Xiang-Rui Wu Feng-Ming Liang Shuai Song Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion Guoji Yanke Zazhi retinal laser photocoagulation ranibizumab anti-vegf therapy macular edema secondary to branch retinal vein occlusion meta-analysis long-term efficacy safety |
| title | Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion |
| title_full | Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion |
| title_fullStr | Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion |
| title_full_unstemmed | Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion |
| title_short | Meta-analysis of long-term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion |
| title_sort | meta analysis of long term efficacy of combined regimen in treatment of macular edema secondary to branch retinal vein occlusion |
| topic | retinal laser photocoagulation ranibizumab anti-vegf therapy macular edema secondary to branch retinal vein occlusion meta-analysis long-term efficacy safety |
| url | http://ies.ijo.cn/cn_publish/2021/1/202101019.pdf |
| work_keys_str_mv | AT xiangruiwu metaanalysisoflongtermefficacyofcombinedregimenintreatmentofmacularedemasecondarytobranchretinalveinocclusion AT fengmingliang metaanalysisoflongtermefficacyofcombinedregimenintreatmentofmacularedemasecondarytobranchretinalveinocclusion AT shuaisong metaanalysisoflongtermefficacyofcombinedregimenintreatmentofmacularedemasecondarytobranchretinalveinocclusion |