Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol
Abstract Background Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, tumors, dementia, and other diseases in th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Complementary Medicine and Therapies |
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| Online Access: | https://doi.org/10.1186/s12906-022-03755-2 |
| _version_ | 1811336275666403328 |
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| author | Peng-Xiang Zhang Lin Zeng Lu Meng Hui-Lin Li Heng-Xia Zhao De-Liang Liu |
| author_facet | Peng-Xiang Zhang Lin Zeng Lu Meng Hui-Lin Li Heng-Xia Zhao De-Liang Liu |
| author_sort | Peng-Xiang Zhang |
| collection | DOAJ |
| description | Abstract Background Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, tumors, dementia, and other diseases in the future when compared to the healthy population. However, prediabetes is mainly treated based on lifestyle intervention, currently without targeted drug treatment plan. Traditional Chinese medicine (TCM), which has a longstanding experience, has been shown in clinical studies to be effective for the treatment of diabetes and its related complications. Furthermore, different dosage forms such as decoction and granule have developed gradually in clinical application. Preliminary studies have found that Huoxue-Jangtang Decoction (HJD), with good hypoglycemic and lipid-regulating effects, is potentially one of the complementary and alternative treatments for prediabetes. Therefore, this project intends to perform a prospective clinical study to observe the clinical effectiveness of HJD on prediabetes and the consistency of the efficacy of formula granules and the elixation. Methods This is a prospective, randomized, double-blind, and placebo-controlled clinical trial. A total of 183 participants are randomly assigned to HJD Formula Granules plus lifestyle intervention, HJD Elixation plus lifestyle intervention, and placebo plus lifestyle intervention. All subjects undergo 1 day of screening before participating in the study, followed by 84 days of drug intervention and observation. During and after treatment, the main outcome measures include fasting blood glucose and 2-hour postprandial blood glucose. Discussion This research attempts to verify the clinical efficacy and possible mechanism of HJD in the treatment of prediabetes, and prove the consistency of HJD Formula Granules with HJD Elixation. This study also aims to provide a treatment that is both effective and safe for prediabetic patients. Trial registration ClinicalTrials.gov Identifier: ChiCTR2200060813, Registered 12 June 2022. |
| first_indexed | 2024-04-13T17:37:04Z |
| format | Article |
| id | doaj.art-889cb0b6520b4a89b2133fc59e0d830d |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-04-13T17:37:04Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-889cb0b6520b4a89b2133fc59e0d830d2022-12-22T02:37:19ZengBMCBMC Complementary Medicine and Therapies2662-76712022-10-0122111210.1186/s12906-022-03755-2Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocolPeng-Xiang Zhang0Lin Zeng1Lu Meng2Hui-Lin Li3Heng-Xia Zhao4De-Liang Liu5The Fourth Clinical Medical College of Guangzhou University of Chinese MedicineThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen Traditional Chinese Medicine HospitalEndocrinology Department of Shenzhen Traditional Chinese Medicine HospitalEndocrinology Department of Shenzhen Traditional Chinese Medicine HospitalAbstract Background Prediabetes is a hypermetabolic syndrome with blood sugar levels falling between the normal and diabetes. People with prediabetes have a significantly increased chances of developing diabetes, cardiovascular and cerebrovascular diseases, tumors, dementia, and other diseases in the future when compared to the healthy population. However, prediabetes is mainly treated based on lifestyle intervention, currently without targeted drug treatment plan. Traditional Chinese medicine (TCM), which has a longstanding experience, has been shown in clinical studies to be effective for the treatment of diabetes and its related complications. Furthermore, different dosage forms such as decoction and granule have developed gradually in clinical application. Preliminary studies have found that Huoxue-Jangtang Decoction (HJD), with good hypoglycemic and lipid-regulating effects, is potentially one of the complementary and alternative treatments for prediabetes. Therefore, this project intends to perform a prospective clinical study to observe the clinical effectiveness of HJD on prediabetes and the consistency of the efficacy of formula granules and the elixation. Methods This is a prospective, randomized, double-blind, and placebo-controlled clinical trial. A total of 183 participants are randomly assigned to HJD Formula Granules plus lifestyle intervention, HJD Elixation plus lifestyle intervention, and placebo plus lifestyle intervention. All subjects undergo 1 day of screening before participating in the study, followed by 84 days of drug intervention and observation. During and after treatment, the main outcome measures include fasting blood glucose and 2-hour postprandial blood glucose. Discussion This research attempts to verify the clinical efficacy and possible mechanism of HJD in the treatment of prediabetes, and prove the consistency of HJD Formula Granules with HJD Elixation. This study also aims to provide a treatment that is both effective and safe for prediabetic patients. Trial registration ClinicalTrials.gov Identifier: ChiCTR2200060813, Registered 12 June 2022.https://doi.org/10.1186/s12906-022-03755-2PrediabetesHuoxue Jiangtang formulaRandomized controlled trialTraditional Chinese medicine |
| spellingShingle | Peng-Xiang Zhang Lin Zeng Lu Meng Hui-Lin Li Heng-Xia Zhao De-Liang Liu Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol BMC Complementary Medicine and Therapies Prediabetes Huoxue Jiangtang formula Randomized controlled trial Traditional Chinese medicine |
| title | Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol |
| title_full | Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol |
| title_fullStr | Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol |
| title_full_unstemmed | Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol |
| title_short | Observation on clinical effect of Huoxue-Jiangtang decoction formula granules in treating prediabetes: a randomized prospective placebo-controlled double-blind trial protocol |
| title_sort | observation on clinical effect of huoxue jiangtang decoction formula granules in treating prediabetes a randomized prospective placebo controlled double blind trial protocol |
| topic | Prediabetes Huoxue Jiangtang formula Randomized controlled trial Traditional Chinese medicine |
| url | https://doi.org/10.1186/s12906-022-03755-2 |
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