From A to m<sup>6</sup>A: The Emerging Viral Epitranscriptome
There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/6/1049 |
| _version_ | 1797531732516274176 |
|---|---|
| author | Belinda Baquero-Perez Daryl Geers Juana Díez |
| author_facet | Belinda Baquero-Perez Daryl Geers Juana Díez |
| author_sort | Belinda Baquero-Perez |
| collection | DOAJ |
| description | There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that m<sup>6</sup>A modifications play important roles in regulating viral replication by interacting with the cellular m<sup>6</sup>A machinery. In this review, we will exhaustively detail the current knowledge on m<sup>6</sup>A modification, with an emphasis on its function in virus biology. |
| first_indexed | 2024-03-10T10:48:56Z |
| format | Article |
| id | doaj.art-889d80eb1f914a1788efc3ea961a0c6a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T10:48:56Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-889d80eb1f914a1788efc3ea961a0c6a2023-11-21T22:25:02ZengMDPI AGViruses1999-49152021-06-01136104910.3390/v13061049From A to m<sup>6</sup>A: The Emerging Viral EpitranscriptomeBelinda Baquero-Perez0Daryl Geers1Juana Díez2Virology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, SpainVirology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, SpainVirology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, SpainThere are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. <i>N</i><sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important roles in the regulation of the mRNA structure, stability, translation and nuclear export. This modification is also found in viral RNA genomes and in viral mRNAs derived from both RNA and DNA viruses. A growing body of evidence indicates that m<sup>6</sup>A modifications play important roles in regulating viral replication by interacting with the cellular m<sup>6</sup>A machinery. In this review, we will exhaustively detail the current knowledge on m<sup>6</sup>A modification, with an emphasis on its function in virus biology.https://www.mdpi.com/1999-4915/13/6/1049m<sup>6</sup>Aviral infectionepitranscriptomicsRNA modification |
| spellingShingle | Belinda Baquero-Perez Daryl Geers Juana Díez From A to m<sup>6</sup>A: The Emerging Viral Epitranscriptome Viruses m<sup>6</sup>A viral infection epitranscriptomics RNA modification |
| title | From A to m<sup>6</sup>A: The Emerging Viral Epitranscriptome |
| title_full | From A to m<sup>6</sup>A: The Emerging Viral Epitranscriptome |
| title_fullStr | From A to m<sup>6</sup>A: The Emerging Viral Epitranscriptome |
| title_full_unstemmed | From A to m<sup>6</sup>A: The Emerging Viral Epitranscriptome |
| title_short | From A to m<sup>6</sup>A: The Emerging Viral Epitranscriptome |
| title_sort | from a to m sup 6 sup a the emerging viral epitranscriptome |
| topic | m<sup>6</sup>A viral infection epitranscriptomics RNA modification |
| url | https://www.mdpi.com/1999-4915/13/6/1049 |
| work_keys_str_mv | AT belindabaqueroperez fromatomsup6supatheemergingviralepitranscriptome AT darylgeers fromatomsup6supatheemergingviralepitranscriptome AT juanadiez fromatomsup6supatheemergingviralepitranscriptome |