Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013
Abstract Background Previous studies have suggested that blood Cd, Pb exposure, and physical activity levels may influence the development of hypertension. This study aimed to investigate the relationship between blood Cd, Pb levels, and hypertension by the level of physical activity in Korean adult...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-04-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-023-15614-x |
| _version_ | 1827961042946228224 |
|---|---|
| author | Jeoung A Kwon Byungmi Kim Eunji Kim Kisung Kwon |
| author_facet | Jeoung A Kwon Byungmi Kim Eunji Kim Kisung Kwon |
| author_sort | Jeoung A Kwon |
| collection | DOAJ |
| description | Abstract Background Previous studies have suggested that blood Cd, Pb exposure, and physical activity levels may influence the development of hypertension. This study aimed to investigate the relationship between blood Cd, Pb levels, and hypertension by the level of physical activity in Korean adults using The Korea National Health and Nutrition Examination Survey (KNHANES). Methods We used data from the KNHANES (2008–2013), a nationally representative, cross-sectional, population-based study. We included 8,510 participants who had records of blood Cd, Pb and, blood pressure measurements. Multiple logistic regression was used to examine the association between blood Cd and Pb exposure and the development of hypertension, as well as the modifying effects of physical activity levels. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S). Results Following covariates adjustments, we found significant associations of blood Cd and Pb with higher hypertension prevalence. This association was more apparent in low physical activity while blood Cd and Pb concentrations were not significantly associated with hypertension in participants with more activity. Additionally, there was a significant interaction between blood Cd and physical activity on hypertension risk (RERI = 0.17, 95% CI: -0.36–0.7; AP = 0.12, 95% CI: -0.28–0.52; S = 1.75, 95% CI:1.36–2.14). Conclusions Our results suggest that low physical activity may substantially amplify the adverse effects of blood Pb and Cd exposure on hypertension risk. However, interactions were only found for Cd. Further studies are needed to confirm these findings. |
| first_indexed | 2024-04-09T16:20:33Z |
| format | Article |
| id | doaj.art-889e8579b46c46419a0da334768e91b2 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-09T16:20:33Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-889e8579b46c46419a0da334768e91b22023-04-23T11:30:33ZengBMCBMC Public Health1471-24582023-04-0123111110.1186/s12889-023-15614-xInteraction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013Jeoung A Kwon0Byungmi Kim1Eunji Kim2Kisung Kwon3Institute of Health Services Research, Yonsei UniversityNational Cancer Control Institute, National Cancer CenterDepartment of Environmental Medicine, College of Medicine, Ewha Womans UniversityDepartment of Sport Science, College of Art, Cultural & Engineering, Kangwon National UniversityAbstract Background Previous studies have suggested that blood Cd, Pb exposure, and physical activity levels may influence the development of hypertension. This study aimed to investigate the relationship between blood Cd, Pb levels, and hypertension by the level of physical activity in Korean adults using The Korea National Health and Nutrition Examination Survey (KNHANES). Methods We used data from the KNHANES (2008–2013), a nationally representative, cross-sectional, population-based study. We included 8,510 participants who had records of blood Cd, Pb and, blood pressure measurements. Multiple logistic regression was used to examine the association between blood Cd and Pb exposure and the development of hypertension, as well as the modifying effects of physical activity levels. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S). Results Following covariates adjustments, we found significant associations of blood Cd and Pb with higher hypertension prevalence. This association was more apparent in low physical activity while blood Cd and Pb concentrations were not significantly associated with hypertension in participants with more activity. Additionally, there was a significant interaction between blood Cd and physical activity on hypertension risk (RERI = 0.17, 95% CI: -0.36–0.7; AP = 0.12, 95% CI: -0.28–0.52; S = 1.75, 95% CI:1.36–2.14). Conclusions Our results suggest that low physical activity may substantially amplify the adverse effects of blood Pb and Cd exposure on hypertension risk. However, interactions were only found for Cd. Further studies are needed to confirm these findings.https://doi.org/10.1186/s12889-023-15614-xPhysical activityCadmiumLeadBlood pressureHypertensionInteraction |
| spellingShingle | Jeoung A Kwon Byungmi Kim Eunji Kim Kisung Kwon Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013 BMC Public Health Physical activity Cadmium Lead Blood pressure Hypertension Interaction |
| title | Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013 |
| title_full | Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013 |
| title_fullStr | Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013 |
| title_full_unstemmed | Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013 |
| title_short | Interaction between blood cadmium and lead concentration and physical activity on hypertension from the Korean national health and nutrition examination survey in 2008–2013 |
| title_sort | interaction between blood cadmium and lead concentration and physical activity on hypertension from the korean national health and nutrition examination survey in 2008 2013 |
| topic | Physical activity Cadmium Lead Blood pressure Hypertension Interaction |
| url | https://doi.org/10.1186/s12889-023-15614-x |
| work_keys_str_mv | AT jeoungakwon interactionbetweenbloodcadmiumandleadconcentrationandphysicalactivityonhypertensionfromthekoreannationalhealthandnutritionexaminationsurveyin20082013 AT byungmikim interactionbetweenbloodcadmiumandleadconcentrationandphysicalactivityonhypertensionfromthekoreannationalhealthandnutritionexaminationsurveyin20082013 AT eunjikim interactionbetweenbloodcadmiumandleadconcentrationandphysicalactivityonhypertensionfromthekoreannationalhealthandnutritionexaminationsurveyin20082013 AT kisungkwon interactionbetweenbloodcadmiumandleadconcentrationandphysicalactivityonhypertensionfromthekoreannationalhealthandnutritionexaminationsurveyin20082013 |