Characterization of Four Medically Important Toxins from <i>Centruroides huichol</i> Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment

Characterization of Four Medically Important Toxins from <i>Centruroides huichol</i> Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment

<i>Centruroides huichol</i> scorpion venom is lethal to mammals. Analysis of the venom allowed the characterization of four lethal toxins named Chui2, Chui3, Chui4, and Chui5. scFv 10FG2 recognized well all toxins except Chui5 toxin, therefore a partial neutralization of the venom was ob...

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Bibliographic Details
Main Authors: Hugo Valencia-Martínez, Timoteo Olamendi-Portugal, Rita Restano-Cassulini, Hugo Serrano-Posada, Fernando Zamudio, Lourival D. Possani, Lidia Riaño-Umbarila, Baltazar Becerril
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Toxins
Subjects:
affinity maturation
kinetic and thermodynamic parameters
phage display
scFv
scorpion toxins
Online Access:https://www.mdpi.com/2072-6651/14/6/369

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