Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2

Intracellular delivery of Parkin-RING0-based fragments corrects Parkin-induced mitochondrial dysfunction through interaction with SLP-2

Abstract Background Loss-of-function mutations in the PRKN gene, encoding Parkin, are the most common cause of autosomal recessive Parkinson’s disease (PD). We have previously identified mitoch ondrial Stomatin-like protein 2 (SLP-2), which functions in the assembly of respiratory chain proteins, as...

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Hlavní autoři: Alessandra Zanon, Marianna Guida, Alexandros A. Lavdas, Corrado Corti, Maria Paulina Castelo Rueda, Alessandro Negro, Peter P. Pramstaller, Francisco S. Domingues, Andrew A. Hicks, Irene Pichler
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-01-01
Edice:Journal of Translational Medicine
Témata:
Parkinson′s disease
Parkin
SLP-2
Mitochondria
Parkin mini-peptide
On-line přístup:https://doi.org/10.1186/s12967-024-04850-3

Internet

https://doi.org/10.1186/s12967-024-04850-3

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