Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure?
Complete resection of perihilar cholangiocarcinoma (pCCA) is the only potentially curative treatment. Long-term survival data is rare and prognostic analyses are hindered by the rarity of the disease. This study aimed to determine the cure rate and to identify clinicopathological factors that may pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/24/6260 |
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| author | Anne-Marleen van Keulen Pim B. Olthof Matteo Cescon Alfredo Guglielmi William R. Jarnagin Silvio Nadalin Johann Pratschke Francesca Ratti Roberto I. Troisi Bas Groot Koerkamp Stefan Buettner Joris I. Erdmann on behalf of the ‘Perihilar Cholangiocarcinoma Collaboration Group’ |
| author_facet | Anne-Marleen van Keulen Pim B. Olthof Matteo Cescon Alfredo Guglielmi William R. Jarnagin Silvio Nadalin Johann Pratschke Francesca Ratti Roberto I. Troisi Bas Groot Koerkamp Stefan Buettner Joris I. Erdmann on behalf of the ‘Perihilar Cholangiocarcinoma Collaboration Group’ |
| author_sort | Anne-Marleen van Keulen |
| collection | DOAJ |
| description | Complete resection of perihilar cholangiocarcinoma (pCCA) is the only potentially curative treatment. Long-term survival data is rare and prognostic analyses are hindered by the rarity of the disease. This study aimed to determine the cure rate and to identify clinicopathological factors that may preclude cure. All consecutive resections for pathologically confirmed pCCA between 2000 and 2009 in 22 centers worldwide were included in a retrospective cohort study. Each center included its retrospective data series. A total of 460 patients were included with a median follow-up of 10 years for patients alive at last follow-up. Median overall survival (OS) was 29.9 months and 10-year OS was 12.8%. Twenty-nine (6%) patients reached 10-year OS. The observed cure rate was 5%. Factors that virtually precluded cure (i.e., below 1%) according to the mixture cure model included age above 70, Bismuth-Corlette type IV tumors, hepatic artery reconstruction, and positive resection margins. Cure was unlikely (i.e., below 3%) in patients with positive lymph nodes or poor tumor differentiation. These factors need to be considered in patient counseling and long-term follow-up after surgery. |
| first_indexed | 2024-03-10T04:31:54Z |
| format | Article |
| id | doaj.art-88a025237a074087ab9f1b9a5727de5c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:31:54Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-88a025237a074087ab9f1b9a5727de5c2023-11-23T04:06:05ZengMDPI AGCancers2072-66942021-12-011324626010.3390/cancers13246260Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure?Anne-Marleen van Keulen0Pim B. Olthof1Matteo Cescon2Alfredo Guglielmi3William R. Jarnagin4Silvio Nadalin5Johann Pratschke6Francesca Ratti7Roberto I. Troisi8Bas Groot Koerkamp9Stefan Buettner10Joris I. Erdmann11on behalf of the ‘Perihilar Cholangiocarcinoma Collaboration Group’Erasmus Medical Center, Department of Surgery, 3015 GD Rotterdam, The NetherlandsErasmus Medical Center, Department of Surgery, 3015 GD Rotterdam, The NetherlandsGeneral Surgery and Transplantation Unit, Department of Medical and Surgical Sciences, University of Bologna, 40126 Bologna, ItalyUnit of Hepato-Pancreato-Biliary Surgery, Department of Surgery, University of Verona Medical School, 37134 Verona, ItalyDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 1275, USADepartment of General, Visceral and Transplant Surgery, University Hospital Tübingen, 72076 Tübingen, GermanyDepartment of Surgery, Charité—Universitätsmedizin Berlin, 13353 Berlin, GermanyHepatobiliary Surgery Division, San Raffaele Hospital, 20158 Milan, ItalyDepartment of Clinical Medicine and Surgery, Federico II University Hospital Naples, 80131 Napoli, ItalyErasmus Medical Center, Department of Surgery, 3015 GD Rotterdam, The NetherlandsErasmus Medical Center, Department of Surgery, 3015 GD Rotterdam, The NetherlandsDepartment of Surgery, Amsterdam University Medical Centers, 1105 AZ Amsterdam, The NetherlandsComplete resection of perihilar cholangiocarcinoma (pCCA) is the only potentially curative treatment. Long-term survival data is rare and prognostic analyses are hindered by the rarity of the disease. This study aimed to determine the cure rate and to identify clinicopathological factors that may preclude cure. All consecutive resections for pathologically confirmed pCCA between 2000 and 2009 in 22 centers worldwide were included in a retrospective cohort study. Each center included its retrospective data series. A total of 460 patients were included with a median follow-up of 10 years for patients alive at last follow-up. Median overall survival (OS) was 29.9 months and 10-year OS was 12.8%. Twenty-nine (6%) patients reached 10-year OS. The observed cure rate was 5%. Factors that virtually precluded cure (i.e., below 1%) according to the mixture cure model included age above 70, Bismuth-Corlette type IV tumors, hepatic artery reconstruction, and positive resection margins. Cure was unlikely (i.e., below 3%) in patients with positive lymph nodes or poor tumor differentiation. These factors need to be considered in patient counseling and long-term follow-up after surgery.https://www.mdpi.com/2072-6694/13/24/6260perihilar cholangiocarcinomaKlatskin tumorsurgerysurvivalprognosiscure |
| spellingShingle | Anne-Marleen van Keulen Pim B. Olthof Matteo Cescon Alfredo Guglielmi William R. Jarnagin Silvio Nadalin Johann Pratschke Francesca Ratti Roberto I. Troisi Bas Groot Koerkamp Stefan Buettner Joris I. Erdmann on behalf of the ‘Perihilar Cholangiocarcinoma Collaboration Group’ Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure? Cancers perihilar cholangiocarcinoma Klatskin tumor surgery survival prognosis cure |
| title | Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure? |
| title_full | Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure? |
| title_fullStr | Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure? |
| title_full_unstemmed | Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure? |
| title_short | Actual 10-Year Survival after Resection of Perihilar Cholangiocarcinoma: What Factors Preclude a Chance for Cure? |
| title_sort | actual 10 year survival after resection of perihilar cholangiocarcinoma what factors preclude a chance for cure |
| topic | perihilar cholangiocarcinoma Klatskin tumor surgery survival prognosis cure |
| url | https://www.mdpi.com/2072-6694/13/24/6260 |
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