The dual role of microRNA (miR)-20b in cancers: Friend or foe?
Abstract MicroRNAs, as non-coding transcripts, modulate gene expression through RNA silencing under normal physiological conditions. Their aberrant expression has strongly associated with tumorigenesis and cancer development. MiR-20b is one of the crucial miRNAs that regulate essential biological pr...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-022-01019-7 |
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| author | Ahmet İlhan Shayan Golestani Seyyed Ghavam Shafagh Fatemeh Asadi Danyal Daneshdoust Bashar Zuhair Talib Al-Naqeeb Mohammed Mahdi Nemati Fateme Khalatbari Amirhossein Fakhre Yaseri |
| author_facet | Ahmet İlhan Shayan Golestani Seyyed Ghavam Shafagh Fatemeh Asadi Danyal Daneshdoust Bashar Zuhair Talib Al-Naqeeb Mohammed Mahdi Nemati Fateme Khalatbari Amirhossein Fakhre Yaseri |
| author_sort | Ahmet İlhan |
| collection | DOAJ |
| description | Abstract MicroRNAs, as non-coding transcripts, modulate gene expression through RNA silencing under normal physiological conditions. Their aberrant expression has strongly associated with tumorigenesis and cancer development. MiR-20b is one of the crucial miRNAs that regulate essential biological processes such as cell proliferation, apoptosis, autophagy, and migration. Deregulated levels of miR-20b contribute to the early- and advanced stages of cancer. On the other hand, investigations emphasize the tumor suppressor ability of miR-20b. High-throughput strategies are developed to identify miR-20b potential targets, providing the proper insight into its molecular mechanism of action. Moreover, accumulated results suggest that miR-20b exerts its effects through diverse signaling pathways, including PI3K/AKT/mTOR and ERK axes. Restoration of the altered expression levels of miR-20b induces cell apoptosis and reduces invasion and migration. Further, miR-20b can be used as a biomarker in cancer. The current comprehensive review could lead to a better understanding of the miR-20b in either tumorigenesis or tumor regression that may open new avenues for cancer treatment. Video Abstract |
| first_indexed | 2024-04-10T17:17:21Z |
| format | Article |
| id | doaj.art-88a2547460b446f48301faa23d1773e5 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-10T17:17:21Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-88a2547460b446f48301faa23d1773e52023-02-05T12:19:10ZengBMCCell Communication and Signaling1478-811X2023-01-0121111310.1186/s12964-022-01019-7The dual role of microRNA (miR)-20b in cancers: Friend or foe?Ahmet İlhan0Shayan Golestani1Seyyed Ghavam Shafagh2Fatemeh Asadi3Danyal Daneshdoust4Bashar Zuhair Talib Al-Naqeeb5Mohammed Mahdi Nemati6Fateme Khalatbari7Amirhossein Fakhre Yaseri8Department of Medical Biochemistry, Faculty of Medicine, Cukurova UniversityDepartment of Oral and Maxillofacial Surgery, Dental School, Islamic Azad University, Isfahan (Khorasgan) BranchFaculty of Medicine, Iran University of Medical SciencesDepartment of Genetics, Marvdasht Branch, Islamic Azad UniversitySchool of Medicine, Babol University of Medical SciencesAnesthesia Technology Department, Al-Turath University CollegeFaculty of Medicine, Urmia University of Medical SciencesDepartment of Pathology, Mashhad Medical Sciences Branch, Islamic Azad UniversityDepartment of Genetic, Faculty of Medicine, Qazvin University of Medical SciencesAbstract MicroRNAs, as non-coding transcripts, modulate gene expression through RNA silencing under normal physiological conditions. Their aberrant expression has strongly associated with tumorigenesis and cancer development. MiR-20b is one of the crucial miRNAs that regulate essential biological processes such as cell proliferation, apoptosis, autophagy, and migration. Deregulated levels of miR-20b contribute to the early- and advanced stages of cancer. On the other hand, investigations emphasize the tumor suppressor ability of miR-20b. High-throughput strategies are developed to identify miR-20b potential targets, providing the proper insight into its molecular mechanism of action. Moreover, accumulated results suggest that miR-20b exerts its effects through diverse signaling pathways, including PI3K/AKT/mTOR and ERK axes. Restoration of the altered expression levels of miR-20b induces cell apoptosis and reduces invasion and migration. Further, miR-20b can be used as a biomarker in cancer. The current comprehensive review could lead to a better understanding of the miR-20b in either tumorigenesis or tumor regression that may open new avenues for cancer treatment. Video Abstracthttps://doi.org/10.1186/s12964-022-01019-7miRNAsCancermiR-20bApoptosis |
| spellingShingle | Ahmet İlhan Shayan Golestani Seyyed Ghavam Shafagh Fatemeh Asadi Danyal Daneshdoust Bashar Zuhair Talib Al-Naqeeb Mohammed Mahdi Nemati Fateme Khalatbari Amirhossein Fakhre Yaseri The dual role of microRNA (miR)-20b in cancers: Friend or foe? Cell Communication and Signaling miRNAs Cancer miR-20b Apoptosis |
| title | The dual role of microRNA (miR)-20b in cancers: Friend or foe? |
| title_full | The dual role of microRNA (miR)-20b in cancers: Friend or foe? |
| title_fullStr | The dual role of microRNA (miR)-20b in cancers: Friend or foe? |
| title_full_unstemmed | The dual role of microRNA (miR)-20b in cancers: Friend or foe? |
| title_short | The dual role of microRNA (miR)-20b in cancers: Friend or foe? |
| title_sort | dual role of microrna mir 20b in cancers friend or foe |
| topic | miRNAs Cancer miR-20b Apoptosis |
| url | https://doi.org/10.1186/s12964-022-01019-7 |
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