Adenosine Targeting as a New Strategy to Decrease Glioblastoma Aggressiveness

Adenosine Targeting as a New Strategy to Decrease Glioblastoma Aggressiveness

Glioblastoma is the most commonly malignant and aggressive brain tumor, with a high mortality rate. The role of the purine nucleotide adenosine and its interaction with its four subtypes receptors coupled to the different G proteins, A1, A2A, A2B, and A3, and its different physiological functions in...

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Bibliographic Details
Main Authors: Valentina Bova, Alessia Filippone, Giovanna Casili, Marika Lanza, Michela Campolo, Anna Paola Capra, Alberto Repici, Lelio Crupi, Gianmarco Motta, Cristina Colarossi, Giulia Chisari, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
glioblastoma
adenosine
tumor microenvironment
A2AAR antagonist
immune evasion
adenosine receptors
Online Access:https://www.mdpi.com/2072-6694/14/16/4032

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