Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism
Aspirin is a widely used multi-efficiency pharmaceutical, and its environmental residues are frequently detected. However, limited information is available on its effects on the development of the public health pest and saprophytic insect Musca domestica. In this study, it was demonstrated that aspi...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323013490 |
| _version_ | 1797350615112744960 |
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| author | Ting Li Yansong Yin Kexin Zhang Ying Li Xinxin Kong Dan Liu Yu Luo Ruiling Zhang Zhong Zhang |
| author_facet | Ting Li Yansong Yin Kexin Zhang Ying Li Xinxin Kong Dan Liu Yu Luo Ruiling Zhang Zhong Zhang |
| author_sort | Ting Li |
| collection | DOAJ |
| description | Aspirin is a widely used multi-efficiency pharmaceutical, and its environmental residues are frequently detected. However, limited information is available on its effects on the development of the public health pest and saprophytic insect Musca domestica. In this study, it was demonstrated that aspirin inhibits the larval growth of house flies in a concentration-dependent manner. Microbiome analysis indicated that the composition of larval intestinal bacteria was influenced by aspirin but not greatly. The dominant bacterial genus in the aspirin group was still Klebsiella, as in the control group. Transcriptome sequencing and gene set enrichment analysis showed that retinol metabolism was activated after aspirin treatment. High performance liquid chromatography indicated that the content of retinol in larvae was decreased and that of retinoic acid was increased. The addition of β-carotene, a precursor substance of retinol, in feeding promotes larval development and alleviates the inhibitory effect caused by aspirin. In contrast, retinoic acid delayed the larval development of house flies as well as aspirin. Gene expression analysis after aspirin exposure demonstrated that genes involved in the transformation from retinol to retinoic acid were upregulated. Overall, aspirin exposure impairs larval development by activating retinol metabolism in house flies and can be utilized as an effective pesticide. This work uncovers the mechanism underlying the larval development inhibition induced by aspirin in terms of metabolism and genetics, and provides novel functional exploration of a traditional drug for pest management. |
| first_indexed | 2024-03-08T12:48:29Z |
| format | Article |
| id | doaj.art-88a63779a62649f7be0a345bf8d00dcf |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-03-08T12:48:29Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-88a63779a62649f7be0a345bf8d00dcf2024-01-21T05:04:58ZengElsevierEcotoxicology and Environmental Safety0147-65132024-01-01270115845Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolismTing Li0Yansong Yin1Kexin Zhang2Ying Li3Xinxin Kong4Dan Liu5Yu Luo6Ruiling Zhang7Zhong Zhang8School of Life Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, ChinaSchool of Basic Medical Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, ChinaHospital for Skin Diseases, Shandong First Medical University, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, ChinaSchool of Basic Medical Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, ChinaSchool of Basic Medical Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, ChinaSchool of Life Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, ChinaSchool of Life Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, ChinaSchool of Basic Medical Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, China; Corresponding author.School of Life Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, China; Weifang Medical University, Weifang 261021, Shandong, China; Corresponding author at: School of Life Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Taian 271016, Shandong, China.Aspirin is a widely used multi-efficiency pharmaceutical, and its environmental residues are frequently detected. However, limited information is available on its effects on the development of the public health pest and saprophytic insect Musca domestica. In this study, it was demonstrated that aspirin inhibits the larval growth of house flies in a concentration-dependent manner. Microbiome analysis indicated that the composition of larval intestinal bacteria was influenced by aspirin but not greatly. The dominant bacterial genus in the aspirin group was still Klebsiella, as in the control group. Transcriptome sequencing and gene set enrichment analysis showed that retinol metabolism was activated after aspirin treatment. High performance liquid chromatography indicated that the content of retinol in larvae was decreased and that of retinoic acid was increased. The addition of β-carotene, a precursor substance of retinol, in feeding promotes larval development and alleviates the inhibitory effect caused by aspirin. In contrast, retinoic acid delayed the larval development of house flies as well as aspirin. Gene expression analysis after aspirin exposure demonstrated that genes involved in the transformation from retinol to retinoic acid were upregulated. Overall, aspirin exposure impairs larval development by activating retinol metabolism in house flies and can be utilized as an effective pesticide. This work uncovers the mechanism underlying the larval development inhibition induced by aspirin in terms of metabolism and genetics, and provides novel functional exploration of a traditional drug for pest management.http://www.sciencedirect.com/science/article/pii/S0147651323013490AspirinSaprophytic insectsToxic effectMolecular mechanism |
| spellingShingle | Ting Li Yansong Yin Kexin Zhang Ying Li Xinxin Kong Dan Liu Yu Luo Ruiling Zhang Zhong Zhang Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism Ecotoxicology and Environmental Safety Aspirin Saprophytic insects Toxic effect Molecular mechanism |
| title | Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism |
| title_full | Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism |
| title_fullStr | Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism |
| title_full_unstemmed | Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism |
| title_short | Ecotoxicity effect of aspirin on the larvae of Musca domestica through retinol metabolism |
| title_sort | ecotoxicity effect of aspirin on the larvae of musca domestica through retinol metabolism |
| topic | Aspirin Saprophytic insects Toxic effect Molecular mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651323013490 |
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