The Role of the Heat-Shock Proteins in Esophagogastric Cancer
Heat-shock proteins (HSPs) are a family of proteins that have received considerable attention over the last several years. They have been classified into six prominent families: high-molecular-mass HSP, 90, 70, 60, 40, and small heat shock proteins. HSPs participate in protein folding, stability, an...
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2073-4409/11/17/2664 |
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| author | Francisco Tustumi Gabriel Andrade Agareno Ricardo Purchio Galletti Rafael Benjamim Rosa da Silva Julia Grams Quintas Lucas de Abreu Sesconetto Daniel José Szor Nelson Wolosker |
| author_facet | Francisco Tustumi Gabriel Andrade Agareno Ricardo Purchio Galletti Rafael Benjamim Rosa da Silva Julia Grams Quintas Lucas de Abreu Sesconetto Daniel José Szor Nelson Wolosker |
| author_sort | Francisco Tustumi |
| collection | DOAJ |
| description | Heat-shock proteins (HSPs) are a family of proteins that have received considerable attention over the last several years. They have been classified into six prominent families: high-molecular-mass HSP, 90, 70, 60, 40, and small heat shock proteins. HSPs participate in protein folding, stability, and maturation of several proteins during stress, such as in heat, oxidative stress, fever, and inflammation. Due to the immunogenic host’s role in the combat against cancer cells and the role of the inflammation in the cancer control or progression, abnormal expression of these proteins has been associated with many types of cancer, including esophagogastric cancer. This study aims to review all the evidence concerning the role of HSPs in the pathogenesis and prognosis of esophagogastric cancer and their potential role in future treatment options. This narrative review gathers scientific evidence concerning HSPs in relation to esophagus and gastric cancer. All esophagogastric cancer subtypes are included. The role of HSPs in carcinogenesis, prognostication, and therapy for esophagogastric cancer are discussed. The main topics covered are premalignant conditions for gastric cancer atrophic gastritis, Barrett esophagus, and some viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV). HSPs represent new perspectives on the development, prognostication, and treatment of esophagogastric cancer. |
| first_indexed | 2024-03-10T01:56:58Z |
| format | Article |
| id | doaj.art-88a6645a353b40fa9f046000e9253a7b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T01:56:58Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-88a6645a353b40fa9f046000e9253a7b2023-11-23T12:54:51ZengMDPI AGCells2073-44092022-08-011117266410.3390/cells11172664The Role of the Heat-Shock Proteins in Esophagogastric CancerFrancisco Tustumi0Gabriel Andrade Agareno1Ricardo Purchio Galletti2Rafael Benjamim Rosa da Silva3Julia Grams Quintas4Lucas de Abreu Sesconetto5Daniel José Szor6Nelson Wolosker7Department of Gastroenterology, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255, São Paulo 05403-000, SP, BrazilDepartment of Surgery, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo 05652-900, SP, BrazilDepartment of Surgery, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo 05652-900, SP, BrazilDepartment of Surgery, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo 05652-900, SP, BrazilDepartment of Surgery, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo 05652-900, SP, BrazilDepartment of Surgery, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo 05652-900, SP, BrazilDepartment of Gastroenterology, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255, São Paulo 05403-000, SP, BrazilDepartment of Surgery, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627, São Paulo 05652-900, SP, BrazilHeat-shock proteins (HSPs) are a family of proteins that have received considerable attention over the last several years. They have been classified into six prominent families: high-molecular-mass HSP, 90, 70, 60, 40, and small heat shock proteins. HSPs participate in protein folding, stability, and maturation of several proteins during stress, such as in heat, oxidative stress, fever, and inflammation. Due to the immunogenic host’s role in the combat against cancer cells and the role of the inflammation in the cancer control or progression, abnormal expression of these proteins has been associated with many types of cancer, including esophagogastric cancer. This study aims to review all the evidence concerning the role of HSPs in the pathogenesis and prognosis of esophagogastric cancer and their potential role in future treatment options. This narrative review gathers scientific evidence concerning HSPs in relation to esophagus and gastric cancer. All esophagogastric cancer subtypes are included. The role of HSPs in carcinogenesis, prognostication, and therapy for esophagogastric cancer are discussed. The main topics covered are premalignant conditions for gastric cancer atrophic gastritis, Barrett esophagus, and some viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV). HSPs represent new perspectives on the development, prognostication, and treatment of esophagogastric cancer.https://www.mdpi.com/2073-4409/11/17/2664heat-shock proteinsesophageal neoplasm cancersstomach neoplasm |
| spellingShingle | Francisco Tustumi Gabriel Andrade Agareno Ricardo Purchio Galletti Rafael Benjamim Rosa da Silva Julia Grams Quintas Lucas de Abreu Sesconetto Daniel José Szor Nelson Wolosker The Role of the Heat-Shock Proteins in Esophagogastric Cancer Cells heat-shock proteins esophageal neoplasm cancers stomach neoplasm |
| title | The Role of the Heat-Shock Proteins in Esophagogastric Cancer |
| title_full | The Role of the Heat-Shock Proteins in Esophagogastric Cancer |
| title_fullStr | The Role of the Heat-Shock Proteins in Esophagogastric Cancer |
| title_full_unstemmed | The Role of the Heat-Shock Proteins in Esophagogastric Cancer |
| title_short | The Role of the Heat-Shock Proteins in Esophagogastric Cancer |
| title_sort | role of the heat shock proteins in esophagogastric cancer |
| topic | heat-shock proteins esophageal neoplasm cancers stomach neoplasm |
| url | https://www.mdpi.com/2073-4409/11/17/2664 |
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