Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

Bioluminescence Resonance Energy Transfer as a Method to Study Protein-Protein Interactions: Application to G Protein Coupled Receptor Biology

The bioluminescence resonance energy transfer (BRET) approach involves resonance energy transfer between a light-emitting enzyme and fluorescent acceptors. The major advantage of this technique over biochemical methods is that protein-protein interactions (PPI) can be monitored without disrupting th...

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Bibliographic Details
Main Authors: Chayma El Khamlichi, Flora Reverchon-Assadi, Nadège Hervouet-Coste, Lauren Blot, Eric Reiter, Séverine Morisset-Lopez
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
BRET
receptor-protein interactions
G protein-coupled receptors
GPCR signaling
GPCR-interacting proteins
drug discovery
screening
Online Access:https://www.mdpi.com/1420-3049/24/3/537

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