BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
BubR1 is a key component of the spindle assembly checkpoint (SAC). Mutations that reduce BubR1 abundance cause aneuploidization and tumorigenesis in humans and mice, whereas BubR1 overexpression protects against these. However, how supranormal BubR1 expression exerts these beneficial physiological i...
Main Authors: | Robbyn L Weaver, Jazeel F Limzerwala, Ryan M Naylor, Karthik B Jeganathan, Darren J Baker, Jan M van Deursen |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-08-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/16620 |
Similar Items
-
P53 independent pathogenic mechanisms contribute to BubR1 microcephaly
by: Noelle A. Sterling, et al.
Published: (2023-10-01) -
Suppression of Genomic Instabilities Caused by Chromosome Mis-segregation: A Perspective From Studying BubR1 and Sgo1
by: Wei Dai
Published: (2009-12-01) -
Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization
by: Jiao Wang, et al.
Published: (2016-06-01) -
BUBR1 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma
by: Leonor Delgado, et al.
Published: (2022-11-01) -
The establishment of mitotic errors-driven senescence depends on autophagy
by: Andreas Goutas, et al.
Published: (2023-06-01)