Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes
Maternal diabetes is a prevalent pathology that increases the risk of cardiovascular diseases in the offspring, the heart being one of the main target organs affected from the fetal stage until the adult life. Metabolic, pro-oxidant, and proinflammatory alterations in the fetal heart constitute the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.760251/full |
| _version_ | 1818735959790845952 |
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| author | Romina Higa Romina Higa María Laura Leonardi María Laura Leonardi Alicia Jawerbaum Alicia Jawerbaum |
| author_facet | Romina Higa Romina Higa María Laura Leonardi María Laura Leonardi Alicia Jawerbaum Alicia Jawerbaum |
| author_sort | Romina Higa |
| collection | DOAJ |
| description | Maternal diabetes is a prevalent pathology that increases the risk of cardiovascular diseases in the offspring, the heart being one of the main target organs affected from the fetal stage until the adult life. Metabolic, pro-oxidant, and proinflammatory alterations in the fetal heart constitute the first steps in the adverse fetal programming of cardiovascular disease in the context of maternal diabetes. This review discusses both human and experimental studies addressing putative mechanisms involved in this fetal programming of heart damage in maternal diabetes. These include cardiac epigenetic changes, alterations in cardiac carbohydrate and lipid metabolism, damaging effects caused by a pro-oxidant and proinflammatory environment, alterations in the cardiac extracellular matrix remodeling, and specific signaling pathways. Putative actions to prevent cardiovascular impairments in the offspring of mothers with diabetes are also discussed. |
| first_indexed | 2024-12-18T00:29:33Z |
| format | Article |
| id | doaj.art-88b103fc12c244f1a4dfb850b08ec1da |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-18T00:29:33Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-88b103fc12c244f1a4dfb850b08ec1da2022-12-21T21:27:10ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-11-011210.3389/fphys.2021.760251760251Intrauterine Programming of Cardiovascular Diseases in Maternal DiabetesRomina Higa0Romina Higa1María Laura Leonardi2María Laura Leonardi3Alicia Jawerbaum4Alicia Jawerbaum5Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaLaboratory of Reproduction and Metabolism, CONICET-Universidad de Buenos Aires, CEFYBO, Buenos Aires, ArgentinaFacultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaLaboratory of Reproduction and Metabolism, CONICET-Universidad de Buenos Aires, CEFYBO, Buenos Aires, ArgentinaFacultad de Medicina, Universidad de Buenos Aires, Buenos Aires, ArgentinaLaboratory of Reproduction and Metabolism, CONICET-Universidad de Buenos Aires, CEFYBO, Buenos Aires, ArgentinaMaternal diabetes is a prevalent pathology that increases the risk of cardiovascular diseases in the offspring, the heart being one of the main target organs affected from the fetal stage until the adult life. Metabolic, pro-oxidant, and proinflammatory alterations in the fetal heart constitute the first steps in the adverse fetal programming of cardiovascular disease in the context of maternal diabetes. This review discusses both human and experimental studies addressing putative mechanisms involved in this fetal programming of heart damage in maternal diabetes. These include cardiac epigenetic changes, alterations in cardiac carbohydrate and lipid metabolism, damaging effects caused by a pro-oxidant and proinflammatory environment, alterations in the cardiac extracellular matrix remodeling, and specific signaling pathways. Putative actions to prevent cardiovascular impairments in the offspring of mothers with diabetes are also discussed.https://www.frontiersin.org/articles/10.3389/fphys.2021.760251/fullheartoffspringanimal modelhumansdiabetes mellitusintrauterine programming |
| spellingShingle | Romina Higa Romina Higa María Laura Leonardi María Laura Leonardi Alicia Jawerbaum Alicia Jawerbaum Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes Frontiers in Physiology heart offspring animal model humans diabetes mellitus intrauterine programming |
| title | Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes |
| title_full | Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes |
| title_fullStr | Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes |
| title_full_unstemmed | Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes |
| title_short | Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes |
| title_sort | intrauterine programming of cardiovascular diseases in maternal diabetes |
| topic | heart offspring animal model humans diabetes mellitus intrauterine programming |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.760251/full |
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