A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases
Background and objective A number of patients with lung cancer have distant metastases at the time of diagnosis. The most common sites for metastases are liver, brain, etc. However pancreatic metastasis is relatively rare, with an insidious onset and poor prognosis. There are no sufficient recogniti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2019-04-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2019.04.05 |
| _version_ | 1828233753750667264 |
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| author | Yu ZHANG Minjiang CHEN Jing ZHAO Wei ZHONG Yan XU Mengzhao WANG |
| author_facet | Yu ZHANG Minjiang CHEN Jing ZHAO Wei ZHONG Yan XU Mengzhao WANG |
| author_sort | Yu ZHANG |
| collection | DOAJ |
| description | Background and objective A number of patients with lung cancer have distant metastases at the time of diagnosis. The most common sites for metastases are liver, brain, etc. However pancreatic metastasis is relatively rare, with an insidious onset and poor prognosis. There are no sufficient recognition and attention of lung cancer with pancreatic metastasis. The aim of this study was to summarize the pathological characteristics, clinical manifestations, therapies and prognosis of pancreatic metastases of lung cancer, thus further exploring better managements for the best prolonged survival or quality of life. Methods 42 patients of lung carcinoma with confirmed pancreatic metastases hospitalized at the Peking Union Medical College Hospital from January 1998 to December 2018 were identified. We reviewed all medical documentations for complete information including diagnosis, treatment, prognosis features. Results 24 (57%) patients were asymptomatic or presented with non-specific symptoms. 18 (43%) patients had symptoms related to pancreatic metastases, such as acute pancreatitis, obstructive jaundice or pain of lumber back. The median overall survival (OS) was 8.8 months. Multivariate analysis suggested patients with symptoms had a poor prognosis compared with patients without pancreatic symptoms [(hazard ratio, HR)=2.645, 95%CI: 1.013-6.910, P=0.047]. Patients received chemotherapy had better prognosis versus those who did not [HR=0.158, 95%CI: 0.049-0.512, P=0.002]. Conclusion Pancreatic metastasis of lung cancer is rare and the prognosis is poor. Chemotherapy can prolong survival significantly. Local radiotherapy of the pancreas may alleviate local symptoms, improve quality of life, facilitate further systemic chemotherapy for patients to prolong survival. Patients with symptoms related to pancreatic metastases can benefit from the comprehensive treatment of chemotherapy combined with local pancreatic radiotherapy. |
| first_indexed | 2024-04-12T19:45:34Z |
| format | Article |
| id | doaj.art-88b2e8dd025c4e31b1b92a2412d03299 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-12T19:45:34Z |
| publishDate | 2019-04-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-88b2e8dd025c4e31b1b92a2412d032992022-12-22T03:18:59ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872019-04-0122422823210.3779/j.issn.1009-3419.2019.04.05A Retrospective Study of 42 Lung Cancer Patients with Pancreatic MetastasesYu ZHANG0Minjiang CHEN1Jing ZHAO2Wei ZHONG3Yan XU4Mengzhao WANG5Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaBackground and objective A number of patients with lung cancer have distant metastases at the time of diagnosis. The most common sites for metastases are liver, brain, etc. However pancreatic metastasis is relatively rare, with an insidious onset and poor prognosis. There are no sufficient recognition and attention of lung cancer with pancreatic metastasis. The aim of this study was to summarize the pathological characteristics, clinical manifestations, therapies and prognosis of pancreatic metastases of lung cancer, thus further exploring better managements for the best prolonged survival or quality of life. Methods 42 patients of lung carcinoma with confirmed pancreatic metastases hospitalized at the Peking Union Medical College Hospital from January 1998 to December 2018 were identified. We reviewed all medical documentations for complete information including diagnosis, treatment, prognosis features. Results 24 (57%) patients were asymptomatic or presented with non-specific symptoms. 18 (43%) patients had symptoms related to pancreatic metastases, such as acute pancreatitis, obstructive jaundice or pain of lumber back. The median overall survival (OS) was 8.8 months. Multivariate analysis suggested patients with symptoms had a poor prognosis compared with patients without pancreatic symptoms [(hazard ratio, HR)=2.645, 95%CI: 1.013-6.910, P=0.047]. Patients received chemotherapy had better prognosis versus those who did not [HR=0.158, 95%CI: 0.049-0.512, P=0.002]. Conclusion Pancreatic metastasis of lung cancer is rare and the prognosis is poor. Chemotherapy can prolong survival significantly. Local radiotherapy of the pancreas may alleviate local symptoms, improve quality of life, facilitate further systemic chemotherapy for patients to prolong survival. Patients with symptoms related to pancreatic metastases can benefit from the comprehensive treatment of chemotherapy combined with local pancreatic radiotherapy.http://dx.doi.org/10.3779/j.issn.1009-3419.2019.04.05Lung neoplamsmsPancreatic metastasisAcute pancreatitisObstructive jaundiceChemotherapyLocal radiotherapy |
| spellingShingle | Yu ZHANG Minjiang CHEN Jing ZHAO Wei ZHONG Yan XU Mengzhao WANG A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases Chinese Journal of Lung Cancer Lung neoplamsms Pancreatic metastasis Acute pancreatitis Obstructive jaundice Chemotherapy Local radiotherapy |
| title | A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases |
| title_full | A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases |
| title_fullStr | A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases |
| title_full_unstemmed | A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases |
| title_short | A Retrospective Study of 42 Lung Cancer Patients with Pancreatic Metastases |
| title_sort | retrospective study of 42 lung cancer patients with pancreatic metastases |
| topic | Lung neoplamsms Pancreatic metastasis Acute pancreatitis Obstructive jaundice Chemotherapy Local radiotherapy |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2019.04.05 |
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