Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition

Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition

Summary: How cancer cells shift metabolism to aerobic glycolysis is largely unknown. Here, we show that deficiency of α/β-hydrolase domain-containing 5 (Abhd5), an intracellular lipolytic activator that is also known as comparative gene identification 58 (CGI-58), promotes this metabolic shift and e...

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Bibliographic Details
Main Authors: Juanjuan Ou, Hongming Miao, Yinyan Ma, Feng Guo, Jia Deng, Xing Wei, Jie Zhou, Ganfeng Xie, Hang Shi, Bingzhong Xue, Houjie Liang, Liqing Yu
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400970X

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