Blood pressure screening in midlife aids in prediction of dementia later in life
Background: There is substantial evidence that midlife hypertension is a risk factor for late life dementia. Our aim was to investigate if even high blood pressure at a single timepoint in midlife can predict an increased risk for all-cause dementia, Alzheimer’s disease (AD), or vascular dementia (V...
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| Format: | Article |
| Language: | English |
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Upsala Medical Society
2022-01-01
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| Series: | Upsala Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ujms.net/index.php/ujms/article/view/7860/14218 |
| _version_ | 1827835175438909440 |
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| author | Linn Moberg Jerzy Leppert Simon Liljeström Mattias Rehn Lena Kilander Abbas Chabok |
| author_facet | Linn Moberg Jerzy Leppert Simon Liljeström Mattias Rehn Lena Kilander Abbas Chabok |
| author_sort | Linn Moberg |
| collection | DOAJ |
| description | Background: There is substantial evidence that midlife hypertension is a risk factor for late life dementia. Our aim was to investigate if even high blood pressure at a single timepoint in midlife can predict an increased risk for all-cause dementia, Alzheimer’s disease (AD), or vascular dementia (VaD) later in life. Methods: The community-based study population comprised 30,102 dementia-free individuals from the Westmannia Cardiovascular Risk Factors Study. The participants were aged 40 or 50 years when the health examination took place in 1990–2000. Diagnose registers from both hospitals and primary healthcare centers were used to identify individuals who after inclusion to the study developed dementia. The association between midlife high blood pressure (defined as systolic blood pressure >140 and/or diastolic blood pressure >90 mmHg) at a single timepoint and dementia was adjusted for age, gender, body mass index (BMI), fasting blood glucose, education, smoking, and physical activity level. Multivariate binary cox regression analyses were used. Results: After a mean follow-up time of 24 years resulting in 662,244 person/years, 761 (2.5%) individuals had been diagnosed with dementia. Midlife high blood pressure at a single timepoint predicted all-cause dementia (hazard ratio [HR]: 1.22, 95% confidence interval [CI]: 1.02–1.45) and VaD (HR: 2.10, 95% CI: 1.47–3.00) but not AD (HR: 1.06, 95% CI: 0.81–1.38). Conclusion: This study suggests that even midlife high blood pressure at a single timepoint predicts all-cause dementia and more than doubles the risk for VaD later in life independently of established confounders. Even though there was no such association with AD, this strengthens the importance of midlife health examinations in order to identify individuals with hypertension and initiate treatment. |
| first_indexed | 2024-03-12T06:03:52Z |
| format | Article |
| id | doaj.art-88bb3d4863484c6cbf0a73371cae8838 |
| institution | Directory Open Access Journal |
| issn | 0300-9734 2000-1967 |
| language | English |
| last_indexed | 2024-03-12T06:03:52Z |
| publishDate | 2022-01-01 |
| publisher | Upsala Medical Society |
| record_format | Article |
| series | Upsala Journal of Medical Sciences |
| spelling | doaj.art-88bb3d4863484c6cbf0a73371cae88382023-09-03T03:47:23ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672022-01-011271610.48101/ujms.v127.78607860Blood pressure screening in midlife aids in prediction of dementia later in lifeLinn Moberg0Jerzy Leppert1Simon Liljeström2Mattias Rehn3Lena Kilander4Abbas Chabok5Centre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, SwedenCentre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, SwedenCentre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, SwedenCentre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, SwedenDepartment of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, SwedenCentre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, SwedenBackground: There is substantial evidence that midlife hypertension is a risk factor for late life dementia. Our aim was to investigate if even high blood pressure at a single timepoint in midlife can predict an increased risk for all-cause dementia, Alzheimer’s disease (AD), or vascular dementia (VaD) later in life. Methods: The community-based study population comprised 30,102 dementia-free individuals from the Westmannia Cardiovascular Risk Factors Study. The participants were aged 40 or 50 years when the health examination took place in 1990–2000. Diagnose registers from both hospitals and primary healthcare centers were used to identify individuals who after inclusion to the study developed dementia. The association between midlife high blood pressure (defined as systolic blood pressure >140 and/or diastolic blood pressure >90 mmHg) at a single timepoint and dementia was adjusted for age, gender, body mass index (BMI), fasting blood glucose, education, smoking, and physical activity level. Multivariate binary cox regression analyses were used. Results: After a mean follow-up time of 24 years resulting in 662,244 person/years, 761 (2.5%) individuals had been diagnosed with dementia. Midlife high blood pressure at a single timepoint predicted all-cause dementia (hazard ratio [HR]: 1.22, 95% confidence interval [CI]: 1.02–1.45) and VaD (HR: 2.10, 95% CI: 1.47–3.00) but not AD (HR: 1.06, 95% CI: 0.81–1.38). Conclusion: This study suggests that even midlife high blood pressure at a single timepoint predicts all-cause dementia and more than doubles the risk for VaD later in life independently of established confounders. Even though there was no such association with AD, this strengthens the importance of midlife health examinations in order to identify individuals with hypertension and initiate treatment.https://ujms.net/index.php/ujms/article/view/7860/14218midlife hypertensionscreeningdementiapredictionlong-term follow-upprevalence |
| spellingShingle | Linn Moberg Jerzy Leppert Simon Liljeström Mattias Rehn Lena Kilander Abbas Chabok Blood pressure screening in midlife aids in prediction of dementia later in life Upsala Journal of Medical Sciences midlife hypertension screening dementia prediction long-term follow-up prevalence |
| title | Blood pressure screening in midlife aids in prediction of dementia later in life |
| title_full | Blood pressure screening in midlife aids in prediction of dementia later in life |
| title_fullStr | Blood pressure screening in midlife aids in prediction of dementia later in life |
| title_full_unstemmed | Blood pressure screening in midlife aids in prediction of dementia later in life |
| title_short | Blood pressure screening in midlife aids in prediction of dementia later in life |
| title_sort | blood pressure screening in midlife aids in prediction of dementia later in life |
| topic | midlife hypertension screening dementia prediction long-term follow-up prevalence |
| url | https://ujms.net/index.php/ujms/article/view/7860/14218 |
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