Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway Models
The pulmonary administration of pharmaceutical aerosols to patients is affected by age-dependent variations in the anatomy of the upper airways and the inhalation pattern. Considering this aspect, different upper airway models, representing the geometries of adults and preschool children, and a conv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-02-01
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| Series: | Pharmaceutics |
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| Online Access: | http://www.mdpi.com/1999-4923/6/1/36 |
| _version_ | 1811184656857432064 |
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| author | Sandra Lindert Antje Below Joerg Breitkreutz |
| author_facet | Sandra Lindert Antje Below Joerg Breitkreutz |
| author_sort | Sandra Lindert |
| collection | DOAJ |
| description | The pulmonary administration of pharmaceutical aerosols to patients is affected by age-dependent variations in the anatomy of the upper airways and the inhalation pattern. Considering this aspect, different upper airway models, representing the geometries of adults and preschool children, and a conventional induction port according to the European Pharmacopeia were used for in vitro testing of dry powder inhalers with single dosed capsules (Cyclohaler®, Handihaler® and Spinhaler®). Deposition measurements were performed using steady flow rates of 30 and 60 L/min for the Handihaler®/Spinhaler® and 30, 60 and 75 L/min for the Cyclohaler®. The inhalation volume was set at 1 L. For the Cyclohaler®, the in vitro testing was supplemented by a pediatric inhalation profile. Slight differences of pulmonary deposition between the idealized adult (11%–15%) and pediatric (9%–11%) upper airway model were observed for the Cyclohaler®. The applied pediatric inhalation profile resulted in a reduction of pulmonary deposition by 5% compared to steady conditions and indicated the influence of the inhalation pattern on the amount of pulmonary deposited particles. The comparison of two pediatric upper airway models showed no differences. The performance of the Handihaler® was similar to the Cyclohaler®. The Spinhaler® showed an insufficient performance and limited reproducibility in our investigations. |
| first_indexed | 2024-04-11T13:17:14Z |
| format | Article |
| id | doaj.art-88bbdad970ad4eb996819ee29ab189cc |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T13:17:14Z |
| publishDate | 2014-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-88bbdad970ad4eb996819ee29ab189cc2022-12-22T04:22:23ZengMDPI AGPharmaceutics1999-49232014-02-0161365110.3390/pharmaceutics6010036pharmaceutics6010036Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway ModelsSandra Lindert0Antje Below1Joerg Breitkreutz2Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, Duesseldorf 40225, GermanyRottendorf Pharma GmbH, Ennigerloh 59320, GermanyInstitute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University, Duesseldorf 40225, GermanyThe pulmonary administration of pharmaceutical aerosols to patients is affected by age-dependent variations in the anatomy of the upper airways and the inhalation pattern. Considering this aspect, different upper airway models, representing the geometries of adults and preschool children, and a conventional induction port according to the European Pharmacopeia were used for in vitro testing of dry powder inhalers with single dosed capsules (Cyclohaler®, Handihaler® and Spinhaler®). Deposition measurements were performed using steady flow rates of 30 and 60 L/min for the Handihaler®/Spinhaler® and 30, 60 and 75 L/min for the Cyclohaler®. The inhalation volume was set at 1 L. For the Cyclohaler®, the in vitro testing was supplemented by a pediatric inhalation profile. Slight differences of pulmonary deposition between the idealized adult (11%–15%) and pediatric (9%–11%) upper airway model were observed for the Cyclohaler®. The applied pediatric inhalation profile resulted in a reduction of pulmonary deposition by 5% compared to steady conditions and indicated the influence of the inhalation pattern on the amount of pulmonary deposited particles. The comparison of two pediatric upper airway models showed no differences. The performance of the Handihaler® was similar to the Cyclohaler®. The Spinhaler® showed an insufficient performance and limited reproducibility in our investigations.http://www.mdpi.com/1999-4923/6/1/36dry powder inhalersingle dosed capsulesupper airway modelpreschool childrenCyclohalerHandihalerSpinhaler in vitro testing |
| spellingShingle | Sandra Lindert Antje Below Joerg Breitkreutz Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway Models Pharmaceutics dry powder inhaler single dosed capsules upper airway model preschool children Cyclohaler Handihaler Spinhaler in vitro testing |
| title | Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway Models |
| title_full | Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway Models |
| title_fullStr | Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway Models |
| title_full_unstemmed | Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway Models |
| title_short | Performance of Dry Powder Inhalers with Single Dosed Capsules in Preschool Children and Adults Using Improved Upper Airway Models |
| title_sort | performance of dry powder inhalers with single dosed capsules in preschool children and adults using improved upper airway models |
| topic | dry powder inhaler single dosed capsules upper airway model preschool children Cyclohaler Handihaler Spinhaler in vitro testing |
| url | http://www.mdpi.com/1999-4923/6/1/36 |
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