Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch
Itch is a clinical problem that leaves many sufferers insufficiently treated, with over 20 million cases in the United States. This is due to incomplete understanding of its molecular, cellular, and cell-to-cell signaling mechanisms. Transient receptor potential (TRP) ion channels are involved in se...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/14/7591 |
| _version_ | 1797526935957405696 |
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| author | Qiaojuan Zhang Gwendolyn Henry Yong Chen |
| author_facet | Qiaojuan Zhang Gwendolyn Henry Yong Chen |
| author_sort | Qiaojuan Zhang |
| collection | DOAJ |
| description | Itch is a clinical problem that leaves many sufferers insufficiently treated, with over 20 million cases in the United States. This is due to incomplete understanding of its molecular, cellular, and cell-to-cell signaling mechanisms. Transient receptor potential (TRP) ion channels are involved in several sensory modalities including pain, vision, taste, olfaction, hearing, touch, and thermosensation, as well as itch. Relative to the extensive studies on TRPV1 and TRPA1 ion channels in itch modulation, TRPV4 has received relatively little research attention and its mechanisms have remained poorly understood until recently. TRPV4 is expressed in ganglion sensory neurons and a variety of skin cells. Growing evidence in the past few years strongly suggests that TRPV4 in these cells contributes to acute and chronic disease-associated itch. This review focuses on the current experimental evidence involving TRPV4 in itch under pathophysiological conditions and discusses its possible cellular and molecular mechanisms. |
| first_indexed | 2024-03-10T09:36:24Z |
| format | Article |
| id | doaj.art-88bf8165f793482fba6d9f47b5535938 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T09:36:24Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-88bf8165f793482fba6d9f47b55359382023-11-22T04:00:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-012214759110.3390/ijms22147591Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic ItchQiaojuan Zhang0Gwendolyn Henry1Yong Chen2Department of Neurology, Duke University, Durham, NC 27710, USADepartment of Neurology, Duke University, Durham, NC 27710, USADepartment of Neurology, Duke University, Durham, NC 27710, USAItch is a clinical problem that leaves many sufferers insufficiently treated, with over 20 million cases in the United States. This is due to incomplete understanding of its molecular, cellular, and cell-to-cell signaling mechanisms. Transient receptor potential (TRP) ion channels are involved in several sensory modalities including pain, vision, taste, olfaction, hearing, touch, and thermosensation, as well as itch. Relative to the extensive studies on TRPV1 and TRPA1 ion channels in itch modulation, TRPV4 has received relatively little research attention and its mechanisms have remained poorly understood until recently. TRPV4 is expressed in ganglion sensory neurons and a variety of skin cells. Growing evidence in the past few years strongly suggests that TRPV4 in these cells contributes to acute and chronic disease-associated itch. This review focuses on the current experimental evidence involving TRPV4 in itch under pathophysiological conditions and discusses its possible cellular and molecular mechanisms.https://www.mdpi.com/1422-0067/22/14/7591TRPV4itchkeratinocytessensory neuronspruritogen |
| spellingShingle | Qiaojuan Zhang Gwendolyn Henry Yong Chen Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch International Journal of Molecular Sciences TRPV4 itch keratinocytes sensory neurons pruritogen |
| title | Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch |
| title_full | Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch |
| title_fullStr | Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch |
| title_full_unstemmed | Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch |
| title_short | Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch |
| title_sort | emerging role of transient receptor potential vanilloid 4 trpv4 ion channel in acute and chronic itch |
| topic | TRPV4 itch keratinocytes sensory neurons pruritogen |
| url | https://www.mdpi.com/1422-0067/22/14/7591 |
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