Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting
AbstractIntroduction This study aimed to investigate the association between cardiorespiratory fitness (CRF) and perioperative morbidity and long-term mortality in operable patients with early-stage non-small cell lung cancer (NSCLC).Patients and Methods This prospective study included consecutive p...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2295981 |
| _version_ | 1797302155590238208 |
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| author | Yaoshan Dun Ni Cui Shaoping Wu Siqian Fu Jeffrey W. Ripley-Gonzalez Nanjiang Zhou Tanghao Zeng Dezhao Li Mi Chen Yu Ren Wan Yee Lau Yang Du Randal J. Thomas Ray W. Squires Thomas P. Olson Suixin Liu |
| author_facet | Yaoshan Dun Ni Cui Shaoping Wu Siqian Fu Jeffrey W. Ripley-Gonzalez Nanjiang Zhou Tanghao Zeng Dezhao Li Mi Chen Yu Ren Wan Yee Lau Yang Du Randal J. Thomas Ray W. Squires Thomas P. Olson Suixin Liu |
| author_sort | Yaoshan Dun |
| collection | DOAJ |
| description | AbstractIntroduction This study aimed to investigate the association between cardiorespiratory fitness (CRF) and perioperative morbidity and long-term mortality in operable patients with early-stage non-small cell lung cancer (NSCLC).Patients and Methods This prospective study included consecutive patients with early-stage NSCLC who underwent presurgical cardiopulmonary exercise testing between November 2014 and December 2019 (registration number: ChiCTR2100048120). Logistic and Cox proportional hazards regression were applied to evaluate the correlation between CRF and perioperative complications and long-term mortality, respectively. Propensity score overlap weighting was used to adjust for the covariates. We performed sensitivity analyses to determine the stability of our results.Results A total of 895 patients were followed for a median of 40 months [interquartile range 25]. The median age of the patients was 59 years [range 26–83], and 62.5% were male. During the study period, 156 perioperative complications and 146 deaths were observed. Low CRF was associated with a higher risk of death (62.9 versus 33.6 per 1000 person-years; weighted incidence rate difference, 29.34 [95% CI, 0.32 to 58.36] per 1000 person-years) and perioperative morbidity (241.6 versus 141.9 per 1000 surgeries; weighted incidence rate difference, 99.72 [95% CI, 34.75 to 164.70] per 1000 surgeries). A CRF of ≤ 20 ml/kg/min was significantly associated with a high risk of long-term mortality (weighted hazard ratio, 1.98 [95% CI, 1.31 to 2.98], p < 0.001) and perioperative morbidity (weighted odds ratio, 1.93 [1.28 to 2.90], p = 0.002) compared to higher CRF.Conclusion The study found that low CRF is significantly associated with increased perioperative morbidity and long-term mortality in operable patients with early-stage NSCLC. |
| first_indexed | 2024-03-07T23:32:46Z |
| format | Article |
| id | doaj.art-88bfba0b20884060aa2e0d5127f604c4 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-07T23:32:46Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-88bfba0b20884060aa2e0d5127f604c42024-02-20T11:58:23ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155210.1080/07853890.2023.2295981Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weightingYaoshan Dun0Ni Cui1Shaoping Wu2Siqian Fu3Jeffrey W. Ripley-Gonzalez4Nanjiang Zhou5Tanghao Zeng6Dezhao Li7Mi Chen8Yu Ren9Wan Yee Lau10Yang Du11Randal J. Thomas12Ray W. Squires13Thomas P. Olson14Suixin Liu15Division of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaFaculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDivision of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USADivision of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USADivision of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USADivision of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital of Central South University, Changsha, Hunan, ChinaAbstractIntroduction This study aimed to investigate the association between cardiorespiratory fitness (CRF) and perioperative morbidity and long-term mortality in operable patients with early-stage non-small cell lung cancer (NSCLC).Patients and Methods This prospective study included consecutive patients with early-stage NSCLC who underwent presurgical cardiopulmonary exercise testing between November 2014 and December 2019 (registration number: ChiCTR2100048120). Logistic and Cox proportional hazards regression were applied to evaluate the correlation between CRF and perioperative complications and long-term mortality, respectively. Propensity score overlap weighting was used to adjust for the covariates. We performed sensitivity analyses to determine the stability of our results.Results A total of 895 patients were followed for a median of 40 months [interquartile range 25]. The median age of the patients was 59 years [range 26–83], and 62.5% were male. During the study period, 156 perioperative complications and 146 deaths were observed. Low CRF was associated with a higher risk of death (62.9 versus 33.6 per 1000 person-years; weighted incidence rate difference, 29.34 [95% CI, 0.32 to 58.36] per 1000 person-years) and perioperative morbidity (241.6 versus 141.9 per 1000 surgeries; weighted incidence rate difference, 99.72 [95% CI, 34.75 to 164.70] per 1000 surgeries). A CRF of ≤ 20 ml/kg/min was significantly associated with a high risk of long-term mortality (weighted hazard ratio, 1.98 [95% CI, 1.31 to 2.98], p < 0.001) and perioperative morbidity (weighted odds ratio, 1.93 [1.28 to 2.90], p = 0.002) compared to higher CRF.Conclusion The study found that low CRF is significantly associated with increased perioperative morbidity and long-term mortality in operable patients with early-stage NSCLC.https://www.tandfonline.com/doi/10.1080/07853890.2023.2295981Cardiopulmonary exercise testcardiorespiratory fitnessperioperative morbiditymortalitylung cancersurgery |
| spellingShingle | Yaoshan Dun Ni Cui Shaoping Wu Siqian Fu Jeffrey W. Ripley-Gonzalez Nanjiang Zhou Tanghao Zeng Dezhao Li Mi Chen Yu Ren Wan Yee Lau Yang Du Randal J. Thomas Ray W. Squires Thomas P. Olson Suixin Liu Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting Annals of Medicine Cardiopulmonary exercise test cardiorespiratory fitness perioperative morbidity mortality lung cancer surgery |
| title | Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting |
| title_full | Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting |
| title_fullStr | Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting |
| title_full_unstemmed | Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting |
| title_short | Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting |
| title_sort | cardiorespiratory fitness and morbidity and mortality in patients with non small cell lung cancer a prospective study with propensity score weighting |
| topic | Cardiopulmonary exercise test cardiorespiratory fitness perioperative morbidity mortality lung cancer surgery |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2295981 |
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