Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly
The U2 snRNP recognizes the intron during spliceosome assembly. Here the authors report the high-resolution structures of two assembly precursors of human U2 snRNP and reveal that the RNA helicases DDX42 and DDX46 are mutually exclusive in terms of SF3B1-binding.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36489-x |
| _version_ | 1797864225104723968 |
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| author | Fenghua Yang Tong Bian Xiechao Zhan Zhe Chen Zhihan Xing Nicolas A. Larsen Xiaofeng Zhang Yigong Shi |
| author_facet | Fenghua Yang Tong Bian Xiechao Zhan Zhe Chen Zhihan Xing Nicolas A. Larsen Xiaofeng Zhang Yigong Shi |
| author_sort | Fenghua Yang |
| collection | DOAJ |
| description | The U2 snRNP recognizes the intron during spliceosome assembly. Here the authors report the high-resolution structures of two assembly precursors of human U2 snRNP and reveal that the RNA helicases DDX42 and DDX46 are mutually exclusive in terms of SF3B1-binding. |
| first_indexed | 2024-04-09T22:48:18Z |
| format | Article |
| id | doaj.art-88c0359af797477d8a8f0ef88e932c38 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:48:18Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-88c0359af797477d8a8f0ef88e932c382023-03-22T11:44:05ZengNature PortfolioNature Communications2041-17232023-02-0114111110.1038/s41467-023-36489-xMechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assemblyFenghua Yang0Tong Bian1Xiechao Zhan2Zhe Chen3Zhihan Xing4Nicolas A. Larsen5Xiaofeng Zhang6Yigong Shi7College of Life Sciences, Fudan UniversityCollege of Life Sciences, Fudan UniversityResearch Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University; Institute of Biology, Westlake Institute for Advanced StudyState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical UniversityResearch Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University; Institute of Biology, Westlake Institute for Advanced StudyFoghorn TherapeuticsResearch Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University; Institute of Biology, Westlake Institute for Advanced StudyResearch Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University; Institute of Biology, Westlake Institute for Advanced StudyThe U2 snRNP recognizes the intron during spliceosome assembly. Here the authors report the high-resolution structures of two assembly precursors of human U2 snRNP and reveal that the RNA helicases DDX42 and DDX46 are mutually exclusive in terms of SF3B1-binding.https://doi.org/10.1038/s41467-023-36489-x |
| spellingShingle | Fenghua Yang Tong Bian Xiechao Zhan Zhe Chen Zhihan Xing Nicolas A. Larsen Xiaofeng Zhang Yigong Shi Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly Nature Communications |
| title | Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly |
| title_full | Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly |
| title_fullStr | Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly |
| title_full_unstemmed | Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly |
| title_short | Mechanisms of the RNA helicases DDX42 and DDX46 in human U2 snRNP assembly |
| title_sort | mechanisms of the rna helicases ddx42 and ddx46 in human u2 snrnp assembly |
| url | https://doi.org/10.1038/s41467-023-36489-x |
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