Brain-Derived Major Glycoproteins Are Possible Biomarkers for Altered Metabolism of Cerebrospinal Fluid in Neurological Diseases

Brain-Derived Major Glycoproteins Are Possible Biomarkers for Altered Metabolism of Cerebrospinal Fluid in Neurological Diseases

Cerebrospinal fluid (CSF) plays an important role in the homeostasis of the brain. We previously reported that CSF major glycoproteins are biosynthesized in the brain, i.e., lipocalin-type prostaglandin D2 synthase (L-PGDS) and transferrin isoforms carrying unique glycans. Although these glycoprotei...

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Bibliographic Details
Main Authors: Kyoka Hoshi, Mayumi Kanno, Aya Goto, Yoshikazu Ugawa, Katsutoshi Furukawa, Hiroyuki Arai, Masakazu Miyajima, Koichi Takahashi, Kotaro Hattori, Keiichi Kan, Takashi Saito, Yoshiki Yamaguchi, Takashi Mitsufuji, Nobuo Araki, Yasuhiro Hashimoto
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
cerebrospinal fluid
choroid plexus
neuron
prostaglandin D2 synthase
brain-derived transferrin
neurological diseases
Online Access:https://www.mdpi.com/1422-0067/24/7/6084

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