The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension
INTRODUCTION: Non-Dipper hypertension is associated with increased cardiovascular morbidity and mortality. The neutrophil-lymphocyte ratio (NLR) has been associated with poor outcomes in patients with cardiovascular disease. This study aimed to investigate the relationship between dipper and non-dip...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Van Yuzuncu Yil University, School of Medicine
2022-01-01
|
| Series: | Van Tıp Dergisi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-89090 |
| _version_ | 1827608533120581632 |
|---|---|
| author | Halil Akın Önder Bilge |
| author_facet | Halil Akın Önder Bilge |
| author_sort | Halil Akın |
| collection | DOAJ |
| description | INTRODUCTION: Non-Dipper hypertension is associated with increased cardiovascular morbidity and mortality. The neutrophil-lymphocyte ratio (NLR) has been associated with poor outcomes in patients with cardiovascular disease. This study aimed to investigate the relationship between dipper and non-dipper patterns and NLR in resistant hypertension (RHT) patients. METHODS: 164 RHT patients were included in this study. RHT patients were divided into two groups as dipper (n: 76) and non-dipper (n: 88) according to ambulatory blood pressure measurement. NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. RESULTS: 76% of the patients included in the study were female and the average age was 57+-7. Statistically, a significant increase in neutrophil count, red blood cell distribution width (RDW), body mass index and triglyceride values were found in the non-dipper resistant hypertension group compared to the dipper RHT group. Also, the neutrophil-lymphocyte ratio was significantly higher in the non-dipper resistant hypertension group compared to the dipper resistant hypertension group (2.2 (1.94/3.1) vs 1.76 (1.3/2.1)); p <0.001). In the multiple logistic regression analysis, neutrophil-lymphocyte ratio (OR: 2.5, 95% CI: 1.29-4.94, p <0.001) and RDW (OR: 7.1, 95% CI: 3.78-13.4, p <0.001), a significant relationship was found between non-dipper resistant hypertension. DISCUSSION AND CONCLUSION: Our study has shown that the presence of a non-dipper pattern in resistant hypertension patients is associated with inflammation caused by hypertension, and inflammatory indicators such as neutrophil-lymphocyte ratio and RDW were higher in this group of patients. |
| first_indexed | 2024-03-09T07:15:41Z |
| format | Article |
| id | doaj.art-88c17eca713144dab1963c8150a619b9 |
| institution | Directory Open Access Journal |
| issn | 2587-0351 |
| language | English |
| last_indexed | 2024-03-09T07:15:41Z |
| publishDate | 2022-01-01 |
| publisher | Van Yuzuncu Yil University, School of Medicine |
| record_format | Article |
| series | Van Tıp Dergisi |
| spelling | doaj.art-88c17eca713144dab1963c8150a619b92023-12-03T08:39:32ZengVan Yuzuncu Yil University, School of MedicineVan Tıp Dergisi2587-03512022-01-01291546110.5505/vtd.2022.89090VTD-89090The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant HypertensionHalil Akın0Önder Bilge1Sinop Atatürk State Hospital, Department of Cardiology, SinopGazi Yaşargil Education Research Hospital, Department of Cardiology, DiyarbakırINTRODUCTION: Non-Dipper hypertension is associated with increased cardiovascular morbidity and mortality. The neutrophil-lymphocyte ratio (NLR) has been associated with poor outcomes in patients with cardiovascular disease. This study aimed to investigate the relationship between dipper and non-dipper patterns and NLR in resistant hypertension (RHT) patients. METHODS: 164 RHT patients were included in this study. RHT patients were divided into two groups as dipper (n: 76) and non-dipper (n: 88) according to ambulatory blood pressure measurement. NLR was calculated by dividing the number of neutrophils by the number of lymphocytes. RESULTS: 76% of the patients included in the study were female and the average age was 57+-7. Statistically, a significant increase in neutrophil count, red blood cell distribution width (RDW), body mass index and triglyceride values were found in the non-dipper resistant hypertension group compared to the dipper RHT group. Also, the neutrophil-lymphocyte ratio was significantly higher in the non-dipper resistant hypertension group compared to the dipper resistant hypertension group (2.2 (1.94/3.1) vs 1.76 (1.3/2.1)); p <0.001). In the multiple logistic regression analysis, neutrophil-lymphocyte ratio (OR: 2.5, 95% CI: 1.29-4.94, p <0.001) and RDW (OR: 7.1, 95% CI: 3.78-13.4, p <0.001), a significant relationship was found between non-dipper resistant hypertension. DISCUSSION AND CONCLUSION: Our study has shown that the presence of a non-dipper pattern in resistant hypertension patients is associated with inflammation caused by hypertension, and inflammatory indicators such as neutrophil-lymphocyte ratio and RDW were higher in this group of patients.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-89090neutrophil-lymphocyte ratiodippernon-dipperresistant hypertension |
| spellingShingle | Halil Akın Önder Bilge The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension Van Tıp Dergisi neutrophil-lymphocyte ratio dipper non-dipper resistant hypertension |
| title | The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension |
| title_full | The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension |
| title_fullStr | The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension |
| title_full_unstemmed | The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension |
| title_short | The Relationship Between Dipper / Non-Dipper Pattern and Neutrophil-Lymphocyte Ratio in Patients with Resistant Hypertension |
| title_sort | relationship between dipper non dipper pattern and neutrophil lymphocyte ratio in patients with resistant hypertension |
| topic | neutrophil-lymphocyte ratio dipper non-dipper resistant hypertension |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=vtd&un=VTD-89090 |
| work_keys_str_mv | AT halilakın therelationshipbetweendippernondipperpatternandneutrophillymphocyteratioinpatientswithresistanthypertension AT onderbilge therelationshipbetweendippernondipperpatternandneutrophillymphocyteratioinpatientswithresistanthypertension AT halilakın relationshipbetweendippernondipperpatternandneutrophillymphocyteratioinpatientswithresistanthypertension AT onderbilge relationshipbetweendippernondipperpatternandneutrophillymphocyteratioinpatientswithresistanthypertension |