Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areas
Perfluorooctanoic acid (PFOA) is a prevalent, persistent organic pollutant (POP) in the environment. The potential toxic impacts of PFOA on human and ecological health is becoming an increasing concern worldwide. In this study, we investigated the acute toxicity of PFOA in terms of growth, mortality...
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| Format: | Article |
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Elsevier
2021-07-01
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| Series: | Environmental Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666765721000247 |
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| author | Tanmoy Sana Manjurul Islam Chowdhury Panneerselvan Logeshwaran Rajarathnam Dharmarajan Mallavarapu Megharaj |
| author_facet | Tanmoy Sana Manjurul Islam Chowdhury Panneerselvan Logeshwaran Rajarathnam Dharmarajan Mallavarapu Megharaj |
| author_sort | Tanmoy Sana |
| collection | DOAJ |
| description | Perfluorooctanoic acid (PFOA) is a prevalent, persistent organic pollutant (POP) in the environment. The potential toxic impacts of PFOA on human and ecological health is becoming an increasing concern worldwide. In this study, we investigated the acute toxicity of PFOA in terms of growth, mortality, lifespan, neurobehaviour, fecundity and livelihood in Caenorhabditis elegans (C. elegans), a free-living ecologically important animal model species. The acute toxicity (LC50) of PFOA was found to be 4.42 µM (1.83 mg/L). PFOA exposure induced alteration in locomotor behaviour in C. elegans. The reproduction capacity of C. elegans was also reduced after exposure to 0.1 µM (41.4 µg/L) PFOA. Similarly, developmental toxicity was also documented with the reduction in lifespan and alteration in chemotaxis plasticity above 1 µM (414 µg/L) PFOA. C. elegans bioaccumulated PFOA about 520 times than the surrounding concentration when exposed to 0.41 ug/L PFOA. Given that PFOA has demonstrated its toxicological impacts on the reproductive capacity and lifespan of C. elegans at the concentrations that are commonly found at contaminated areas, it is likely that the contamination of PFOA will have detrimental effects on the food chain in both terrestrial and aquatic ecosystems. Thus, the results of this study have significant implications for the ecological risk assessment and remediation of PFOA. |
| first_indexed | 2024-12-17T07:11:10Z |
| format | Article |
| id | doaj.art-88c27dcbcb0c43bea4c3f66fa9eec082 |
| institution | Directory Open Access Journal |
| issn | 2666-7657 |
| language | English |
| last_indexed | 2024-12-17T07:11:10Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environmental Advances |
| spelling | doaj.art-88c27dcbcb0c43bea4c3f66fa9eec0822022-12-21T21:59:02ZengElsevierEnvironmental Advances2666-76572021-07-014100053Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areasTanmoy Sana0Manjurul Islam Chowdhury1Panneerselvan Logeshwaran2Rajarathnam Dharmarajan3Mallavarapu Megharaj4Global Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, The University of Newcastle, ATC Building, University Drive, Callaghan, NSW 2308, AustraliaGlobal Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, The University of Newcastle, ATC Building, University Drive, Callaghan, NSW 2308, AustraliaGlobal Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, The University of Newcastle, ATC Building, University Drive, Callaghan, NSW 2308, AustraliaGlobal Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, The University of Newcastle, ATC Building, University Drive, Callaghan, NSW 2308, AustraliaGlobal Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, The University of Newcastle, ATC Building, University Drive, Callaghan, NSW 2308, Australia; Cooperative Research Centre for Contamination Assessment and Remediation of the Environment (CRC CARE), The University of Newcastle, ATC Building, University Drive, Callaghan, NSW 2308, Australia; Corresponding author at: Global Centre for Environmental Remediation (GCER), College of Engineering, Science and Environment, The University of Newcastle, ATC Building, University Drive, Callaghan, NSW 2308, Australia.Perfluorooctanoic acid (PFOA) is a prevalent, persistent organic pollutant (POP) in the environment. The potential toxic impacts of PFOA on human and ecological health is becoming an increasing concern worldwide. In this study, we investigated the acute toxicity of PFOA in terms of growth, mortality, lifespan, neurobehaviour, fecundity and livelihood in Caenorhabditis elegans (C. elegans), a free-living ecologically important animal model species. The acute toxicity (LC50) of PFOA was found to be 4.42 µM (1.83 mg/L). PFOA exposure induced alteration in locomotor behaviour in C. elegans. The reproduction capacity of C. elegans was also reduced after exposure to 0.1 µM (41.4 µg/L) PFOA. Similarly, developmental toxicity was also documented with the reduction in lifespan and alteration in chemotaxis plasticity above 1 µM (414 µg/L) PFOA. C. elegans bioaccumulated PFOA about 520 times than the surrounding concentration when exposed to 0.41 ug/L PFOA. Given that PFOA has demonstrated its toxicological impacts on the reproductive capacity and lifespan of C. elegans at the concentrations that are commonly found at contaminated areas, it is likely that the contamination of PFOA will have detrimental effects on the food chain in both terrestrial and aquatic ecosystems. Thus, the results of this study have significant implications for the ecological risk assessment and remediation of PFOA.http://www.sciencedirect.com/science/article/pii/S2666765721000247Behavioural toxicityCaenorhabditis elegansPerfluorooctanoic acidPFOAReproductive toxicity |
| spellingShingle | Tanmoy Sana Manjurul Islam Chowdhury Panneerselvan Logeshwaran Rajarathnam Dharmarajan Mallavarapu Megharaj Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areas Environmental Advances Behavioural toxicity Caenorhabditis elegans Perfluorooctanoic acid PFOA Reproductive toxicity |
| title | Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areas |
| title_full | Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areas |
| title_fullStr | Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areas |
| title_full_unstemmed | Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areas |
| title_short | Perfluorooctanoic acid (PFOA) induces behavioural, reproductive and developmental toxicological impacts in Caenorhabditis elegans at concentrations relevant to the contaminated areas |
| title_sort | perfluorooctanoic acid pfoa induces behavioural reproductive and developmental toxicological impacts in caenorhabditis elegans at concentrations relevant to the contaminated areas |
| topic | Behavioural toxicity Caenorhabditis elegans Perfluorooctanoic acid PFOA Reproductive toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S2666765721000247 |
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