Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study
Background Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital‐based studies suggest that African Americans may have reduced...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1161/JAHA.115.001831 |
| _version_ | 1818032833935966208 |
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| author | Deepak K. Gupta Brian Claggett Quinn Wells Susan Cheng Man Li Nisa Maruthur Elizabeth Selvin Josef Coresh Suma Konety Kenneth R. Butler Thomas Mosley Eric Boerwinkle Ron Hoogeveen Christie M. Ballantyne Scott D. Solomon |
| author_facet | Deepak K. Gupta Brian Claggett Quinn Wells Susan Cheng Man Li Nisa Maruthur Elizabeth Selvin Josef Coresh Suma Konety Kenneth R. Butler Thomas Mosley Eric Boerwinkle Ron Hoogeveen Christie M. Ballantyne Scott D. Solomon |
| author_sort | Deepak K. Gupta |
| collection | DOAJ |
| description | Background Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital‐based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community‐based cohorts are lacking. Methods and Results We examined plasma N‐terminal pro B‐type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996–1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P<0.0001). In multivariable models, adjusted log NTproBNP levels were 40% lower (95% confidence interval [CI], −43, −36) in African Americans, compared to Caucasians, which was consistent across subgroups of age, gender, HTN, diabetes, insulin resistance, and obesity. African‐American race was also significantly associated with having nondetectable NTproBNP (adjusted OR, 5.74; 95% CI, 4.22, 7.80). In multivariable analyses in African Americans, a 10% increase in genetic European ancestry was associated with a 7% (95% CI, 1, 13) increase in adjusted log NTproBNP. Conclusions African Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for HTN and its sequalae in this population. |
| first_indexed | 2024-12-10T06:13:40Z |
| format | Article |
| id | doaj.art-88c5461b617746f89315e6b4ac3b56e6 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-10T06:13:40Z |
| publishDate | 2015-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-88c5461b617746f89315e6b4ac3b56e62022-12-22T01:59:30ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802015-05-0145n/an/a10.1161/JAHA.115.001831Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities StudyDeepak K. Gupta0Brian Claggett1Quinn Wells2Susan Cheng3Man Li4Nisa Maruthur5Elizabeth Selvin6Josef Coresh7Suma Konety8Kenneth R. Butler9Thomas Mosley10Eric Boerwinkle11Ron Hoogeveen12Christie M. Ballantyne13Scott D. Solomon14Vanderbilt Heart and Vascular Institute Vanderbilt University Medical Center Nashville TNBrigham and Women's Hospital Harvard Medical School Boston MAVanderbilt Heart and Vascular Institute Vanderbilt University Medical Center Nashville TNBrigham and Women's Hospital Harvard Medical School Boston MADepartment of Epidemiology Johns Hopkins University Baltimore MDDepartment of Medicine Johns Hopkins University Baltimore MDDepartment of Epidemiology Johns Hopkins University Baltimore MDDepartment of Epidemiology Johns Hopkins University Baltimore MDDivision of General Internal Medicine Department of Medicine University of Minnesota Minneapolis MNDivision of Geriatrics Department of Medicine University of Mississippi Jackson MSDivision of Geriatrics Department of Medicine University of Mississippi Jackson MSDivision of Epidemiology and Public Health University of Texas‐Houston Houston TXSection of Cardiovascular Research Department of Medicine Baylor College of Medicine and Houston Methodist Debakey Heart and Vascular Center Houston TXSection of Cardiovascular Research Department of Medicine Baylor College of Medicine and Houston Methodist Debakey Heart and Vascular Center Houston TXBrigham and Women's Hospital Harvard Medical School Boston MABackground Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital‐based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community‐based cohorts are lacking. Methods and Results We examined plasma N‐terminal pro B‐type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996–1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P<0.0001). In multivariable models, adjusted log NTproBNP levels were 40% lower (95% confidence interval [CI], −43, −36) in African Americans, compared to Caucasians, which was consistent across subgroups of age, gender, HTN, diabetes, insulin resistance, and obesity. African‐American race was also significantly associated with having nondetectable NTproBNP (adjusted OR, 5.74; 95% CI, 4.22, 7.80). In multivariable analyses in African Americans, a 10% increase in genetic European ancestry was associated with a 7% (95% CI, 1, 13) increase in adjusted log NTproBNP. Conclusions African Americans have lower levels of plasma NTproBNP than Caucasians, which may be partially owing to genetic variation. Low natriuretic peptide levels in African Americans may contribute to the greater risk for HTN and its sequalae in this population.https://doi.org/10.1161/JAHA.115.001831ancestry informative markersdeficiencyhypertensionnatriuretic peptiderace |
| spellingShingle | Deepak K. Gupta Brian Claggett Quinn Wells Susan Cheng Man Li Nisa Maruthur Elizabeth Selvin Josef Coresh Suma Konety Kenneth R. Butler Thomas Mosley Eric Boerwinkle Ron Hoogeveen Christie M. Ballantyne Scott D. Solomon Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease ancestry informative markers deficiency hypertension natriuretic peptide race |
| title | Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study |
| title_full | Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study |
| title_fullStr | Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study |
| title_full_unstemmed | Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study |
| title_short | Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study |
| title_sort | racial differences in circulating natriuretic peptide levels the atherosclerosis risk in communities study |
| topic | ancestry informative markers deficiency hypertension natriuretic peptide race |
| url | https://doi.org/10.1161/JAHA.115.001831 |
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