SARS-CoV-2 ORF8 as a Modulator of Cytokine Induction: Evidence and Search for Molecular Mechanisms

SARS-CoV-2 ORF8 as a Modulator of Cytokine Induction: Evidence and Search for Molecular Mechanisms

Severe cases of SARS-CoV-2 infection are characterized by an immune response that leads to the overproduction of pro-inflammatory cytokines, resulting in lung damage, cardiovascular symptoms, hematologic symptoms, acute kidney injury and multiple organ failure that can lead to death. This remarkable...

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Bibliographic Details
Main Authors: Marília Inês Móvio, Giovana Waner Carneiro de Almeida, Isabella das Graças Lopes Martines, Gilmara Barros de Lima, Sergio Daishi Sasaki, Alexandre Hiroaki Kihara, Emma Poole, Michael Nevels, Maria Cristina Carlan da Silva
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
ORF8
cytokine storm
Online Access:https://www.mdpi.com/1999-4915/16/1/161

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