Biomarkers of endometriosis: How far have we come and where are we going?
Endometriosis is a common gynaecological disease that is characterized by endometrium-like tissue outside the uterine cavity. Endometriosis significantly compromises the quality of life of women and is a major cause of infertility. The gold standard for diagnosis of endometriosis is visual inspectio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2021-06-01
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| Series: | Zdravniški Vestnik |
| Subjects: | |
| Online Access: | https://vestnik.szd.si/index.php/ZdravVest/article/view/3056 |
| _version_ | 1819289963075731456 |
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| author | Vid Janša Joško Osredkar Eda Vrtačnik Bokal Tea Lanišnik Rižner Helena Ban Frangež |
| author_facet | Vid Janša Joško Osredkar Eda Vrtačnik Bokal Tea Lanišnik Rižner Helena Ban Frangež |
| author_sort | Vid Janša |
| collection | DOAJ |
| description | Endometriosis is a common gynaecological disease that is characterized by endometrium-like tissue outside the uterine cavity. Endometriosis significantly compromises the quality of life of women and is a major cause of infertility. The gold standard for diagnosis of endometriosis is visual inspection by laparoscopy, which significantly prolongs the time to final diagnosis. This lack of non-invasive diagnostic approaches is why the discovery of biomarkers for endometriosis has been defined as a research priority. In this report, we describe hypothesis-driven and hypothesis-generating approaches for biomarker discovery, along with some important potential biomarkers of endometriosis and their diagnostic characteristics, sensitivities, and specificities. Finally, we present our perspective on the discovery of biomarkers for endometriosis, and discuss some results from our previous and more recent studies. Future studies must focus on improving patient quality of life rather than on discovering significant differences, and therefore close collaboration between clinicians and pre-clinical researchers is essential. |
| first_indexed | 2024-12-24T03:15:11Z |
| format | Article |
| id | doaj.art-88c5f6131dca47b39411dc80895fb062 |
| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-24T03:15:11Z |
| publishDate | 2021-06-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-88c5f6131dca47b39411dc80895fb0622022-12-21T17:17:40ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242021-06-01905-625626510.6016/ZdravVestn.30563056Biomarkers of endometriosis: How far have we come and where are we going?Vid Janša0Joško Osredkar1Eda Vrtačnik Bokal2Tea Lanišnik Rižner3Helena Ban Frangež4Department of Gynecology, Division of Gynaecology, University Medical Centre Ljubljana, Ljubljana, SloveniaInstitute for Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, SloveniaDepartment of reproductive medicine, Division of Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaInstitute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaDepartment of reproductive medicine, Division of Gynaecology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaEndometriosis is a common gynaecological disease that is characterized by endometrium-like tissue outside the uterine cavity. Endometriosis significantly compromises the quality of life of women and is a major cause of infertility. The gold standard for diagnosis of endometriosis is visual inspection by laparoscopy, which significantly prolongs the time to final diagnosis. This lack of non-invasive diagnostic approaches is why the discovery of biomarkers for endometriosis has been defined as a research priority. In this report, we describe hypothesis-driven and hypothesis-generating approaches for biomarker discovery, along with some important potential biomarkers of endometriosis and their diagnostic characteristics, sensitivities, and specificities. Finally, we present our perspective on the discovery of biomarkers for endometriosis, and discuss some results from our previous and more recent studies. Future studies must focus on improving patient quality of life rather than on discovering significant differences, and therefore close collaboration between clinicians and pre-clinical researchers is essential.https://vestnik.szd.si/index.php/ZdravVest/article/view/3056endometriosisdiagnosisbiomarkersproteomicshypothesis generating |
| spellingShingle | Vid Janša Joško Osredkar Eda Vrtačnik Bokal Tea Lanišnik Rižner Helena Ban Frangež Biomarkers of endometriosis: How far have we come and where are we going? Zdravniški Vestnik endometriosis diagnosis biomarkers proteomics hypothesis generating |
| title | Biomarkers of endometriosis: How far have we come and where are we going? |
| title_full | Biomarkers of endometriosis: How far have we come and where are we going? |
| title_fullStr | Biomarkers of endometriosis: How far have we come and where are we going? |
| title_full_unstemmed | Biomarkers of endometriosis: How far have we come and where are we going? |
| title_short | Biomarkers of endometriosis: How far have we come and where are we going? |
| title_sort | biomarkers of endometriosis how far have we come and where are we going |
| topic | endometriosis diagnosis biomarkers proteomics hypothesis generating |
| url | https://vestnik.szd.si/index.php/ZdravVest/article/view/3056 |
| work_keys_str_mv | AT vidjansa biomarkersofendometriosishowfarhavewecomeandwherearewegoing AT joskoosredkar biomarkersofendometriosishowfarhavewecomeandwherearewegoing AT edavrtacnikbokal biomarkersofendometriosishowfarhavewecomeandwherearewegoing AT tealanisnikrizner biomarkersofendometriosishowfarhavewecomeandwherearewegoing AT helenabanfrangez biomarkersofendometriosishowfarhavewecomeandwherearewegoing |