Antibody-dependent enhancement of coronavirus
Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220307311 |
| _version_ | 1819173339990589440 |
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| author | Jieqi Wen Yifan Cheng Rongsong Ling Yarong Dai Boxuan Huang Wenjie Huang Siyan Zhang Yizhou Jiang |
| author_facet | Jieqi Wen Yifan Cheng Rongsong Ling Yarong Dai Boxuan Huang Wenjie Huang Siyan Zhang Yizhou Jiang |
| author_sort | Jieqi Wen |
| collection | DOAJ |
| description | Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe. The novel coronavirus poses a great challenge and has caused a wave of panic. In this review, antibody-dependent enhancements in dengue virus and two kinds of coronavirus are summarized. Possible solutions for the effects are reported. We also speculate that ADE may exist in SARS-CoV-2. |
| first_indexed | 2024-12-22T20:21:31Z |
| format | Article |
| id | doaj.art-88c8c83841bc4292be803b9724152cc5 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-22T20:21:31Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-88c8c83841bc4292be803b9724152cc52022-12-21T18:13:50ZengElsevierInternational Journal of Infectious Diseases1201-97122020-11-01100483489Antibody-dependent enhancement of coronavirusJieqi Wen0Yifan Cheng1Rongsong Ling2Yarong Dai3Boxuan Huang4Wenjie Huang5Siyan Zhang6Yizhou Jiang7Institute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaInstitute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaCorresponding author at: Institute for Advanced Study, Shenzhen University, Shenzhen 518067, China.; Institute for Advanced Study, Shenzhen University, Shenzhen 518067, ChinaAntibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe. The novel coronavirus poses a great challenge and has caused a wave of panic. In this review, antibody-dependent enhancements in dengue virus and two kinds of coronavirus are summarized. Possible solutions for the effects are reported. We also speculate that ADE may exist in SARS-CoV-2.http://www.sciencedirect.com/science/article/pii/S1201971220307311Antibody-dependent enhancement (ADE)Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Severe acute respiratory syndrome coronavirus (SARS-CoV)Middle East respiratory syndrome coronavirus (MERS-CoV) |
| spellingShingle | Jieqi Wen Yifan Cheng Rongsong Ling Yarong Dai Boxuan Huang Wenjie Huang Siyan Zhang Yizhou Jiang Antibody-dependent enhancement of coronavirus International Journal of Infectious Diseases Antibody-dependent enhancement (ADE) Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Severe acute respiratory syndrome coronavirus (SARS-CoV) Middle East respiratory syndrome coronavirus (MERS-CoV) |
| title | Antibody-dependent enhancement of coronavirus |
| title_full | Antibody-dependent enhancement of coronavirus |
| title_fullStr | Antibody-dependent enhancement of coronavirus |
| title_full_unstemmed | Antibody-dependent enhancement of coronavirus |
| title_short | Antibody-dependent enhancement of coronavirus |
| title_sort | antibody dependent enhancement of coronavirus |
| topic | Antibody-dependent enhancement (ADE) Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Severe acute respiratory syndrome coronavirus (SARS-CoV) Middle East respiratory syndrome coronavirus (MERS-CoV) |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220307311 |
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