Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias

Impaired Right Ventricular Calcium Cycling Is an Early Risk Factor in R14del-Phospholamban Arrhythmias

The inherited mutation (R14del) in the calcium regulatory protein phospholamban (PLN) is linked to malignant ventricular arrhythmia with poor prognosis starting at adolescence. However, the underlying early mechanisms that may serve as prognostic factors remain elusive. This study generated humanize...

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Bibliographic Details
Main Authors: Kobra Haghighi, George Gardner, Elizabeth Vafiadaki, Mohit Kumar, Lisa C. Green, Jianyong Ma, Jeffrey S. Crocker, Sheryl Koch, Demetrios A. Arvanitis, Phillip Bidwell, Jack Rubinstein, Rutger van de Leur, Pieter A. Doevendans, Fadi G. Akar, Michael Tranter, Hong-Sheng Wang, Sakthivel Sadayappan, Deeptankar DeMazumder, Despina Sanoudou, Roger J. Hajjar, Francesca Stillitano, Evangelia G. Kranias
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Journal of Personalized Medicine
Subjects:
arrhythmia
calcium
phospholamban
mutant
Online Access:https://www.mdpi.com/2075-4426/11/6/502

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