The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes

The HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes

Abstract Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramatic increase in chromatin accessibility downstream of genes. Here, we show that...

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Bibliographic Details
Main Authors: Lara Djakovic, Thomas Hennig, Katharina Reinisch, Andrea Milić, Adam W. Whisnant, Katharina Wolf, Elena Weiß, Tobias Haas, Arnhild Grothey, Christopher S. Jürges, Michael Kluge, Elmar Wolf, Florian Erhard, Caroline C. Friedel, Lars Dölken
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40217-w

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