Review of Dancing Parasites in Lymphatic Filariasis
Lymphatic filariasis is an infection transmitted by blood-sucking mosquitoes with filarial nematodes of the species Wuchereria bancrofti, Brugia malayi und B. timori. It is prevalent in tropical countries throughout the world, with more than 60 million people infected and more than 1 billion living...
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2019-03-01
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| Series: | Ultrasound International Open |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-0918-3678 |
| _version_ | 1818945446191562752 |
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| author | Christoph F. Dietrich Nitin Chaubal Achim Hoerauf Kerstin Kling Markus Schindler Piontek Ludwig Steffgen Sabine Mand Yi Dong |
| author_facet | Christoph F. Dietrich Nitin Chaubal Achim Hoerauf Kerstin Kling Markus Schindler Piontek Ludwig Steffgen Sabine Mand Yi Dong |
| author_sort | Christoph F. Dietrich |
| collection | DOAJ |
| description | Lymphatic filariasis is an infection transmitted by blood-sucking mosquitoes with filarial nematodes of the species Wuchereria bancrofti, Brugia malayi und B. timori. It is prevalent in tropical countries throughout the world, with more than 60 million people infected and more than 1 billion living in areas with the risk of transmission. Worm larvae with a length of less than 1 mm are transmitted by mosquitoes, develop in human lymphatic tissue to adult worms with a length of 7–10 cm, live in the human body for up to 10 years and produce millions of microfilariae, which can be transmitted further by mosquitoes. The adult worms can be easily observed by ultrasonography because of their size and fast movements (the so-called “filarial dance sign”), which can be differentiated from other movements (e. g., blood in venous vessels) by their characteristic movement profile in pulsed-wave Doppler mode. Therapeutic options include (combinations of) ivermectin, albendazole, diethylcarbamazine and doxycycline. The latter depletes endosymbiotic Wolbachia bacteria from the worms and thus sterilizes and later kills the adult worms (macrofilaricidal or adulticidal effect). |
| first_indexed | 2024-12-20T07:59:14Z |
| format | Article |
| id | doaj.art-88cadf2f144a4f76b6eb0da65b43662a |
| institution | Directory Open Access Journal |
| issn | 2509-596X 2199-7152 |
| language | English |
| last_indexed | 2024-12-20T07:59:14Z |
| publishDate | 2019-03-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | Ultrasound International Open |
| spelling | doaj.art-88cadf2f144a4f76b6eb0da65b43662a2022-12-21T19:47:34ZengGeorg Thieme Verlag KGUltrasound International Open2509-596X2199-71522019-03-010502E65E7410.1055/a-0918-3678Review of Dancing Parasites in Lymphatic FilariasisChristoph F. Dietrich0Nitin Chaubal1Achim Hoerauf2Kerstin Kling3Markus Schindler Piontek4Ludwig Steffgen5Sabine Mand6Yi Dong7Caritas-Krankenhaus, Medizinische Klinik 2, Bad Mergentheim, GermanyThane Ultrasound Centre, Thane Ultrasound Centre, Thane, IndiaInstitut für Med. Mikrobiologie, Immunologie und Parasitologie (IMMIP), Universität Bonn, Bonn, GermanyDepartment of Infectious Disease Epidemiology, Robert Koch-Institute, Berlin, GermanyCaritas Krankenhaus Bad Mergentheim, Academic Teaching Hospital of the University of Würzburg, Medical Clinic 2, Bad Mergentheim, GermanyTrainings-Zentrum Ultraschall-Diagnostik LS GmbH, Ultrasound, Mainleus, GermanyInstitut für Med. Mikrobiologie, Immunologie und Parasitologie (IMMIP), Universität Bonn, Bonn, GermanyZhongshan Hospital, Ultrasound, Shanghai, ChinaLymphatic filariasis is an infection transmitted by blood-sucking mosquitoes with filarial nematodes of the species Wuchereria bancrofti, Brugia malayi und B. timori. It is prevalent in tropical countries throughout the world, with more than 60 million people infected and more than 1 billion living in areas with the risk of transmission. Worm larvae with a length of less than 1 mm are transmitted by mosquitoes, develop in human lymphatic tissue to adult worms with a length of 7–10 cm, live in the human body for up to 10 years and produce millions of microfilariae, which can be transmitted further by mosquitoes. The adult worms can be easily observed by ultrasonography because of their size and fast movements (the so-called “filarial dance sign”), which can be differentiated from other movements (e. g., blood in venous vessels) by their characteristic movement profile in pulsed-wave Doppler mode. Therapeutic options include (combinations of) ivermectin, albendazole, diethylcarbamazine and doxycycline. The latter depletes endosymbiotic Wolbachia bacteria from the worms and thus sterilizes and later kills the adult worms (macrofilaricidal or adulticidal effect).http://www.thieme-connect.de/DOI/DOI?10.1055/a-0918-3678parasiteguidelineelastographycontrast-enhanced ultrasound |
| spellingShingle | Christoph F. Dietrich Nitin Chaubal Achim Hoerauf Kerstin Kling Markus Schindler Piontek Ludwig Steffgen Sabine Mand Yi Dong Review of Dancing Parasites in Lymphatic Filariasis Ultrasound International Open parasite guideline elastography contrast-enhanced ultrasound |
| title | Review of Dancing Parasites in Lymphatic Filariasis |
| title_full | Review of Dancing Parasites in Lymphatic Filariasis |
| title_fullStr | Review of Dancing Parasites in Lymphatic Filariasis |
| title_full_unstemmed | Review of Dancing Parasites in Lymphatic Filariasis |
| title_short | Review of Dancing Parasites in Lymphatic Filariasis |
| title_sort | review of dancing parasites in lymphatic filariasis |
| topic | parasite guideline elastography contrast-enhanced ultrasound |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-0918-3678 |
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