An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells

An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells

<i>Background:</i> Upregulation of anti-apoptotic Bcl-2 proteins in advanced prostate cancer leads to therapeutic resistance by prevention of cell death. New therapeutic approaches aim to target the Bcl-2 proteins for the restoration of apoptosis. <i>Methods:</i> The immunoto...

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Bibliographic Details
Main Authors: Anie P. Masilamani, Viviane Dettmer-Monaco, Gianni Monaco, Toni Cathomen, Irina Kuckuck, Susanne Schultze-Seemann, Nathalie Huber, Philipp Wolf
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
prostate cancer
PSMA
targeted therapy
combination therapy
immunotoxin
ABT-737
Online Access:https://www.mdpi.com/2072-6694/12/6/1648

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