Role of resveratrol in inhibiting pathological cardiac remodeling
Cardiovascular disease is a group of diseases with high mortality in clinic, including hypertension, coronary heart disease, cardiomyopathy, heart valve disease, heart failure, to name a few. In the development of cardiovascular diseases, pathological cardiac remodeling is the most common cardiac pa...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.924473/full |
| _version_ | 1811337657379192832 |
|---|---|
| author | Shaowei Fan Yuanhui Hu Yaping You Wenjing Xue Ruoning Chai Xuesong Zhang Xintian Shou Jingjing Shi |
| author_facet | Shaowei Fan Yuanhui Hu Yaping You Wenjing Xue Ruoning Chai Xuesong Zhang Xintian Shou Jingjing Shi |
| author_sort | Shaowei Fan |
| collection | DOAJ |
| description | Cardiovascular disease is a group of diseases with high mortality in clinic, including hypertension, coronary heart disease, cardiomyopathy, heart valve disease, heart failure, to name a few. In the development of cardiovascular diseases, pathological cardiac remodeling is the most common cardiac pathological change, which often becomes a domino to accelerate the deterioration of the disease. Therefore, inhibiting pathological cardiac remodeling may delay the occurrence and development of cardiovascular diseases and provide patients with greater long-term benefits. Resveratrol is a non-flavonoid polyphenol compound. It mainly exists in grapes, berries, peanuts and red wine, and has cardiovascular protective effects, such as anti-oxidation, inhibiting inflammatory reaction, antithrombotic, dilating blood vessels, inhibiting apoptosis and delaying atherosclerosis. At present, the research of resveratrol has made rich progress. This review aims to summarize the possible mechanism of resveratrol against pathological cardiac remodeling, in order to provide some help for the in-depth exploration of the mechanism of inhibiting pathological cardiac remodeling and the development and research of drug targets. |
| first_indexed | 2024-04-13T17:58:00Z |
| format | Article |
| id | doaj.art-88cc56fb11c14979a8c648b1f53b1327 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T17:58:00Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-88cc56fb11c14979a8c648b1f53b13272022-12-22T02:36:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.924473924473Role of resveratrol in inhibiting pathological cardiac remodelingShaowei Fan0Yuanhui Hu1Yaping You2Wenjing Xue3Ruoning Chai4Xuesong Zhang5Xintian Shou6Jingjing Shi7Department of cardiological medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaDepartment of cardiological medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaDepartment of cardiological medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of cardiological medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaDepartment of cardiological medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaGraduate School of Beijing University of Chinese Medicine, Beijing, ChinaDepartment of cardiological medicine, China Academy of Chinese Medical Sciences Guang’anmen Hospital, Beijing, ChinaCardiovascular disease is a group of diseases with high mortality in clinic, including hypertension, coronary heart disease, cardiomyopathy, heart valve disease, heart failure, to name a few. In the development of cardiovascular diseases, pathological cardiac remodeling is the most common cardiac pathological change, which often becomes a domino to accelerate the deterioration of the disease. Therefore, inhibiting pathological cardiac remodeling may delay the occurrence and development of cardiovascular diseases and provide patients with greater long-term benefits. Resveratrol is a non-flavonoid polyphenol compound. It mainly exists in grapes, berries, peanuts and red wine, and has cardiovascular protective effects, such as anti-oxidation, inhibiting inflammatory reaction, antithrombotic, dilating blood vessels, inhibiting apoptosis and delaying atherosclerosis. At present, the research of resveratrol has made rich progress. This review aims to summarize the possible mechanism of resveratrol against pathological cardiac remodeling, in order to provide some help for the in-depth exploration of the mechanism of inhibiting pathological cardiac remodeling and the development and research of drug targets.https://www.frontiersin.org/articles/10.3389/fphar.2022.924473/fullresveratrolcardiac remodelingoxidative stressmitochondrial biogenesisautophagymyocardial fibrosis |
| spellingShingle | Shaowei Fan Yuanhui Hu Yaping You Wenjing Xue Ruoning Chai Xuesong Zhang Xintian Shou Jingjing Shi Role of resveratrol in inhibiting pathological cardiac remodeling Frontiers in Pharmacology resveratrol cardiac remodeling oxidative stress mitochondrial biogenesis autophagy myocardial fibrosis |
| title | Role of resveratrol in inhibiting pathological cardiac remodeling |
| title_full | Role of resveratrol in inhibiting pathological cardiac remodeling |
| title_fullStr | Role of resveratrol in inhibiting pathological cardiac remodeling |
| title_full_unstemmed | Role of resveratrol in inhibiting pathological cardiac remodeling |
| title_short | Role of resveratrol in inhibiting pathological cardiac remodeling |
| title_sort | role of resveratrol in inhibiting pathological cardiac remodeling |
| topic | resveratrol cardiac remodeling oxidative stress mitochondrial biogenesis autophagy myocardial fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.924473/full |
| work_keys_str_mv | AT shaoweifan roleofresveratrolininhibitingpathologicalcardiacremodeling AT yuanhuihu roleofresveratrolininhibitingpathologicalcardiacremodeling AT yapingyou roleofresveratrolininhibitingpathologicalcardiacremodeling AT wenjingxue roleofresveratrolininhibitingpathologicalcardiacremodeling AT ruoningchai roleofresveratrolininhibitingpathologicalcardiacremodeling AT xuesongzhang roleofresveratrolininhibitingpathologicalcardiacremodeling AT xintianshou roleofresveratrolininhibitingpathologicalcardiacremodeling AT jingjingshi roleofresveratrolininhibitingpathologicalcardiacremodeling |