Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study
Although decreased macular pigment density is associated with the development of age-related macular degeneration (AMD), exactly how this decrease may contribute to the development of AMD is still not fully understood. In this study, we investigated the relationship between macular pigment optical d...
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/16/5312 |
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| author | Hiroki Tsujinaka Keigo Saeki Kenji Obayashi Tomo Nishi Tetsuo Ueda Nahoko Ogata |
| author_facet | Hiroki Tsujinaka Keigo Saeki Kenji Obayashi Tomo Nishi Tetsuo Ueda Nahoko Ogata |
| author_sort | Hiroki Tsujinaka |
| collection | DOAJ |
| description | Although decreased macular pigment density is associated with the development of age-related macular degeneration (AMD), exactly how this decrease may contribute to the development of AMD is still not fully understood. In this study, we investigated the relationship between macular pigment optical density (MPOD) and estimated glomerular filtration rate (eGFR). MPOD was measured using MPS II (Electron Technology, Cambridge, UK) in 137 participants who showed no clinical signs of AMD at 3 months after cataract surgery, and simple and multiple linear regression analyses were performed to determine the associations with age, sex, abdominal circumference, diabetes, hypertension, smoking, intraocular lens color, visual acuity before and after surgery, and eGFR. The participants were divided into two groups based on the median MPOD (0.58): the high-pigment and low-pigment groups. The mean value of eGFR in the high-pigment group was significantly higher than that in the low-pigment group (64.2 vs. 58.1, <i>p</i> = 0.02). The simple linear regression analysis revealed a significant positive association between MPOD and eGFR (β = 0.0034, 95% confidence interval [CI]: 0.0011–0.0056, <i>p</i> = 0.0038), and this association was independent of age, sex, abdominal circumference, diabetes, smoking, hypertension, best-corrected visual acuity (BCVA) before surgery, BCVA after surgery, and intraocular lens color (β = 0.0033, 95% CI: 0.00090–0.0058, <i>p</i> = 0.0076). These results show a strong association of renal dysfunction with the decrease in MPOD. |
| first_indexed | 2024-03-10T23:50:36Z |
| format | Article |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T23:50:36Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-88cd00a3935a40cfb2ef477d903365a02023-11-19T01:41:19ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011216531210.3390/jcm12165312Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional StudyHiroki Tsujinaka0Keigo Saeki1Kenji Obayashi2Tomo Nishi3Tetsuo Ueda4Nahoko Ogata5Department of Ophthalmology, Nara Medical University, Kashihara 634-8521, Nara, JapanDepartment of Epidemiology, Nara Medical University, Kashihara 634-8521, Nara, JapanDepartment of Epidemiology, Nara Medical University, Kashihara 634-8521, Nara, JapanDepartment of Ophthalmology, Nara Medical University, Kashihara 634-8521, Nara, JapanDepartment of Ophthalmology, Nara Medical University, Kashihara 634-8521, Nara, JapanDepartment of Ophthalmology, Nara Medical University, Kashihara 634-8521, Nara, JapanAlthough decreased macular pigment density is associated with the development of age-related macular degeneration (AMD), exactly how this decrease may contribute to the development of AMD is still not fully understood. In this study, we investigated the relationship between macular pigment optical density (MPOD) and estimated glomerular filtration rate (eGFR). MPOD was measured using MPS II (Electron Technology, Cambridge, UK) in 137 participants who showed no clinical signs of AMD at 3 months after cataract surgery, and simple and multiple linear regression analyses were performed to determine the associations with age, sex, abdominal circumference, diabetes, hypertension, smoking, intraocular lens color, visual acuity before and after surgery, and eGFR. The participants were divided into two groups based on the median MPOD (0.58): the high-pigment and low-pigment groups. The mean value of eGFR in the high-pigment group was significantly higher than that in the low-pigment group (64.2 vs. 58.1, <i>p</i> = 0.02). The simple linear regression analysis revealed a significant positive association between MPOD and eGFR (β = 0.0034, 95% confidence interval [CI]: 0.0011–0.0056, <i>p</i> = 0.0038), and this association was independent of age, sex, abdominal circumference, diabetes, smoking, hypertension, best-corrected visual acuity (BCVA) before surgery, BCVA after surgery, and intraocular lens color (β = 0.0033, 95% CI: 0.00090–0.0058, <i>p</i> = 0.0076). These results show a strong association of renal dysfunction with the decrease in MPOD.https://www.mdpi.com/2077-0383/12/16/5312macular pigment optical densityestimated glomerular filtration rateage-related macular degeneration |
| spellingShingle | Hiroki Tsujinaka Keigo Saeki Kenji Obayashi Tomo Nishi Tetsuo Ueda Nahoko Ogata Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study Journal of Clinical Medicine macular pigment optical density estimated glomerular filtration rate age-related macular degeneration |
| title | Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study |
| title_full | Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study |
| title_fullStr | Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study |
| title_full_unstemmed | Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study |
| title_short | Positive Association between Macular Pigment Optical Density and Glomerular Filtration Rate: A Cross-Sectional Study |
| title_sort | positive association between macular pigment optical density and glomerular filtration rate a cross sectional study |
| topic | macular pigment optical density estimated glomerular filtration rate age-related macular degeneration |
| url | https://www.mdpi.com/2077-0383/12/16/5312 |
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