Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter
AMP activated protein kinase (AMPK) is a master regulator of cellular metabolism, but how AMPK activity is spatiotemporally regulated remains unclear. Here, Schmitt et al develop a sensitive biosensor for AMPK, which they use to uncover mechanisms for AMPK activity in the lysosome and nucleus.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31190-x |
| _version_ | 1811219086837809152 |
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| author | Danielle L. Schmitt Stephanie D. Curtis Anne C. Lyons Jin-fan Zhang Mingyuan Chen Catherine Y. He Sohum Mehta Reuben J. Shaw Jin Zhang |
| author_facet | Danielle L. Schmitt Stephanie D. Curtis Anne C. Lyons Jin-fan Zhang Mingyuan Chen Catherine Y. He Sohum Mehta Reuben J. Shaw Jin Zhang |
| author_sort | Danielle L. Schmitt |
| collection | DOAJ |
| description | AMP activated protein kinase (AMPK) is a master regulator of cellular metabolism, but how AMPK activity is spatiotemporally regulated remains unclear. Here, Schmitt et al develop a sensitive biosensor for AMPK, which they use to uncover mechanisms for AMPK activity in the lysosome and nucleus. |
| first_indexed | 2024-04-12T07:19:31Z |
| format | Article |
| id | doaj.art-88cdfdd5c4b54f57a416c571887e2b1a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T07:19:31Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-88cdfdd5c4b54f57a416c571887e2b1a2022-12-22T03:42:22ZengNature PortfolioNature Communications2041-17232022-07-0113111210.1038/s41467-022-31190-xSpatial regulation of AMPK signaling revealed by a sensitive kinase activity reporterDanielle L. Schmitt0Stephanie D. Curtis1Anne C. Lyons2Jin-fan Zhang3Mingyuan Chen4Catherine Y. He5Sohum Mehta6Reuben J. Shaw7Jin Zhang8Department of Pharmacology, University of California San DiegoMolecular and Cell Biology Laboratory, The Salk Institute for Biological StudiesDepartment of Bioengineering, University of California San DiegoDepartment of Bioengineering, University of California San DiegoDepartment of Bioengineering, University of California San DiegoDepartment of Pharmacology, University of California San DiegoDepartment of Pharmacology, University of California San DiegoMolecular and Cell Biology Laboratory, The Salk Institute for Biological StudiesDepartment of Pharmacology, University of California San DiegoAMP activated protein kinase (AMPK) is a master regulator of cellular metabolism, but how AMPK activity is spatiotemporally regulated remains unclear. Here, Schmitt et al develop a sensitive biosensor for AMPK, which they use to uncover mechanisms for AMPK activity in the lysosome and nucleus.https://doi.org/10.1038/s41467-022-31190-x |
| spellingShingle | Danielle L. Schmitt Stephanie D. Curtis Anne C. Lyons Jin-fan Zhang Mingyuan Chen Catherine Y. He Sohum Mehta Reuben J. Shaw Jin Zhang Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter Nature Communications |
| title | Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter |
| title_full | Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter |
| title_fullStr | Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter |
| title_full_unstemmed | Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter |
| title_short | Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter |
| title_sort | spatial regulation of ampk signaling revealed by a sensitive kinase activity reporter |
| url | https://doi.org/10.1038/s41467-022-31190-x |
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