Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysis
Summary: Background: To compare overall survival in patients with clinical T1-3N0-1 thoracic esophageal squamous cell carcinoma treated with surgery or definitive chemoradiation therapy (CRT). Methods: We used propensity-score matching to derive 1:1 cohorts of surgery versus definitive CRT. Statist...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Asian Journal of Surgery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958418301040 |
| _version_ | 1811285565366075392 |
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| author | Xu-Yuan Li He-San Luo Sheng-Xi Wu Ze-Sen Du Chun-Peng Zheng Zhi-Yong Wu |
| author_facet | Xu-Yuan Li He-San Luo Sheng-Xi Wu Ze-Sen Du Chun-Peng Zheng Zhi-Yong Wu |
| author_sort | Xu-Yuan Li |
| collection | DOAJ |
| description | Summary: Background: To compare overall survival in patients with clinical T1-3N0-1 thoracic esophageal squamous cell carcinoma treated with surgery or definitive chemoradiation therapy (CRT). Methods: We used propensity-score matching to derive 1:1 cohorts of surgery versus definitive CRT. Statistical analysis was performed using χ2 or Fisher's exact tests. Survival functions were estimated using Kaplan–Meier survival plots, and survival distributions were compared using log-rank tests. Cox proportional hazards modeling was used to analyze the factors affecting overall survival. Results: A total of 334 patients treated with surgery and 252 treated with definitive CRT were included. 129 (38.6%) of 334 patients had recurrence after surgery versus 118 (46.8%) of 252 after definitive CRT. Before matching, the median overall survival were 39.5 months (95% CI, 28.8–50.2) and 23.5 months (95% CI, 18.5–28.5) (P < 0.001) in the surgery and definitive CRT group, respectively. After matching (112 patients in each treatment group), median overall survival was 43.6 months (95% CI, 28.1–59.1) with surgery versus 19.3 months (95% CI, 14.4–24.2) with CRT (P < 0.001). Conclusions: In this retrospective analysis, surgery was associated with better overall survival compared with definitive CRT. Keywords: Esophageal squamous cell carcinoma, Surgery, Chemoradiotherapy |
| first_indexed | 2024-04-13T02:46:53Z |
| format | Article |
| id | doaj.art-88d04a3c6c2e4f1c9f02ec584c6fbd34 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-04-13T02:46:53Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-88d04a3c6c2e4f1c9f02ec584c6fbd342022-12-22T03:06:00ZengElsevierAsian Journal of Surgery1015-95842019-01-01421350355Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysisXu-Yuan Li0He-San Luo1Sheng-Xi Wu2Ze-Sen Du3Chun-Peng Zheng4Zhi-Yong Wu5Department of Medical Oncology, Shantou Central Hospital, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Shantou Central Hospital, Shantou, Guangdong, ChinaDepartment of Radiation Oncology, Shantou Central Hospital, Shantou, Guangdong, ChinaDepartment of Surgical Oncology, Shantou Central Hospital, Shantou, Guangdong, ChinaDepartment of Surgical Oncology, Shantou Central Hospital, Shantou, Guangdong, China; Corresponding author. Waima Road 114, Shantou, China. Fax-number: +86-0754-88550540.Department of Surgical Oncology, Shantou Central Hospital, Shantou, Guangdong, ChinaSummary: Background: To compare overall survival in patients with clinical T1-3N0-1 thoracic esophageal squamous cell carcinoma treated with surgery or definitive chemoradiation therapy (CRT). Methods: We used propensity-score matching to derive 1:1 cohorts of surgery versus definitive CRT. Statistical analysis was performed using χ2 or Fisher's exact tests. Survival functions were estimated using Kaplan–Meier survival plots, and survival distributions were compared using log-rank tests. Cox proportional hazards modeling was used to analyze the factors affecting overall survival. Results: A total of 334 patients treated with surgery and 252 treated with definitive CRT were included. 129 (38.6%) of 334 patients had recurrence after surgery versus 118 (46.8%) of 252 after definitive CRT. Before matching, the median overall survival were 39.5 months (95% CI, 28.8–50.2) and 23.5 months (95% CI, 18.5–28.5) (P < 0.001) in the surgery and definitive CRT group, respectively. After matching (112 patients in each treatment group), median overall survival was 43.6 months (95% CI, 28.1–59.1) with surgery versus 19.3 months (95% CI, 14.4–24.2) with CRT (P < 0.001). Conclusions: In this retrospective analysis, surgery was associated with better overall survival compared with definitive CRT. Keywords: Esophageal squamous cell carcinoma, Surgery, Chemoradiotherapyhttp://www.sciencedirect.com/science/article/pii/S1015958418301040 |
| spellingShingle | Xu-Yuan Li He-San Luo Sheng-Xi Wu Ze-Sen Du Chun-Peng Zheng Zhi-Yong Wu Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysis Asian Journal of Surgery |
| title | Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysis |
| title_full | Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysis |
| title_fullStr | Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysis |
| title_full_unstemmed | Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysis |
| title_short | Definitive chemoradiation therapy or surgery for clinical T1-3N0-1M0 thoracic esophageal squamous cell carcinoma: A propensity score matching analysis |
| title_sort | definitive chemoradiation therapy or surgery for clinical t1 3n0 1m0 thoracic esophageal squamous cell carcinoma a propensity score matching analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1015958418301040 |
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