Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort study
Abstract Background Little is known about the association between the COVID‐19 pandemic and early survival among newly diagnosed cancer patients. Methods This retrospective population‐based cohort study used linked administrative datasets from Ontario, Canada. Adults (≥18 years) who received a cance...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5861 |
| _version_ | 1827932372564180992 |
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| author | Rui Fu Rinku Sutradhar Qing Li Pabiththa Kamalraj Anna Dare Timothy P. Hanna Kelvin K. W. Chan Jonathan C. Irish Natalie Coburn Julie Hallet Simron Singh Ambica Parmar Craig C. Earle Lauren Lapointe‐Shaw Monika K. Krzyzanowska Alexander V. Louie Alyson Mahar David R. Urbach Daniel I. McIsaac Danny Enepekides David Gomez Nicole J. Look Hong Jill Tinmouth Antoine Eskander |
| author_facet | Rui Fu Rinku Sutradhar Qing Li Pabiththa Kamalraj Anna Dare Timothy P. Hanna Kelvin K. W. Chan Jonathan C. Irish Natalie Coburn Julie Hallet Simron Singh Ambica Parmar Craig C. Earle Lauren Lapointe‐Shaw Monika K. Krzyzanowska Alexander V. Louie Alyson Mahar David R. Urbach Daniel I. McIsaac Danny Enepekides David Gomez Nicole J. Look Hong Jill Tinmouth Antoine Eskander |
| author_sort | Rui Fu |
| collection | DOAJ |
| description | Abstract Background Little is known about the association between the COVID‐19 pandemic and early survival among newly diagnosed cancer patients. Methods This retrospective population‐based cohort study used linked administrative datasets from Ontario, Canada. Adults (≥18 years) who received a cancer diagnosis between March 15 and December 31, 2020, were included in a pandemic cohort, while those diagnosed during the same dates in 2018/2019 were included in a pre‐pandemic cohort. All patients were followed for one full year after the date of diagnosis. Cox proportional hazards regression models were used to assess survival in relation to the pandemic, patient characteristics at diagnosis, and the modality of first cancer treatment as a time‐varying covariate. Interaction terms were explored to measure the pandemic association with survival for each cancer type. Results Among 179,746 patients, 53,387 (29.7%) were in the pandemic cohort and 37,741 (21.0%) died over the first post‐diagnosis year. No association between the pandemic and survival was found when adjusting for patient characteristics at diagnosis (HR 0.99 [95% CI 0.96–1.01]), while marginally better survival was found for the pandemic cohort when the modality of treatment was additionally considered (HR 0.97 [95% CI 0.95–0.99]). When examining each cancer type, only a new melanoma diagnosis was associated with a worse survival in the pandemic cohort (HR 1.25 [95% CI 1.05–1.49]). Conclusions Among patients able to receive a cancer diagnosis during the pandemic, one‐year overall survival was not different than those diagnosed in the previous 2 years. This study highlights the complex nature of the COVID‐19 pandemic impact on cancer care. |
| first_indexed | 2024-03-13T07:07:44Z |
| format | Article |
| id | doaj.art-88d1d600525e42fa9ed5252b53c0be68 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-13T07:07:44Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-88d1d600525e42fa9ed5252b53c0be682023-06-06T07:30:47ZengWileyCancer Medicine2045-76342023-05-011210118491185910.1002/cam4.5861Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort studyRui Fu0Rinku Sutradhar1Qing Li2Pabiththa Kamalraj3Anna Dare4Timothy P. Hanna5Kelvin K. W. Chan6Jonathan C. Irish7Natalie Coburn8Julie Hallet9Simron Singh10Ambica Parmar11Craig C. Earle12Lauren Lapointe‐Shaw13Monika K. Krzyzanowska14Alexander V. Louie15Alyson Mahar16David R. Urbach17Daniel I. McIsaac18Danny Enepekides19David Gomez20Nicole J. Look Hong21Jill Tinmouth22Antoine Eskander23ICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaDepartment of Otolaryngology–Head and Neck Surgery University of Toronto Toronto Ontario CanadaICES Toronto Ontario CanadaDivision of Cancer Care and Epidemiology, Cancer Research Institute Queen's University Kingston Ontario CanadaInstitute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health University of Toronto Toronto Ontario CanadaInstitute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health University of Toronto Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaDepartment of Radiation Oncology University of Toronto Toronto Ontario CanadaSchool of Nursing Queen's University Kingston Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaDepartment of Otolaryngology–Head and Neck Surgery University of Toronto Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaICES Toronto Ontario CanadaAbstract Background Little is known about the association between the COVID‐19 pandemic and early survival among newly diagnosed cancer patients. Methods This retrospective population‐based cohort study used linked administrative datasets from Ontario, Canada. Adults (≥18 years) who received a cancer diagnosis between March 15 and December 31, 2020, were included in a pandemic cohort, while those diagnosed during the same dates in 2018/2019 were included in a pre‐pandemic cohort. All patients were followed for one full year after the date of diagnosis. Cox proportional hazards regression models were used to assess survival in relation to the pandemic, patient characteristics at diagnosis, and the modality of first cancer treatment as a time‐varying covariate. Interaction terms were explored to measure the pandemic association with survival for each cancer type. Results Among 179,746 patients, 53,387 (29.7%) were in the pandemic cohort and 37,741 (21.0%) died over the first post‐diagnosis year. No association between the pandemic and survival was found when adjusting for patient characteristics at diagnosis (HR 0.99 [95% CI 0.96–1.01]), while marginally better survival was found for the pandemic cohort when the modality of treatment was additionally considered (HR 0.97 [95% CI 0.95–0.99]). When examining each cancer type, only a new melanoma diagnosis was associated with a worse survival in the pandemic cohort (HR 1.25 [95% CI 1.05–1.49]). Conclusions Among patients able to receive a cancer diagnosis during the pandemic, one‐year overall survival was not different than those diagnosed in the previous 2 years. This study highlights the complex nature of the COVID‐19 pandemic impact on cancer care.https://doi.org/10.1002/cam4.5861cancercancer detectioncancer survivorshipCOVID‐19oncology |
| spellingShingle | Rui Fu Rinku Sutradhar Qing Li Pabiththa Kamalraj Anna Dare Timothy P. Hanna Kelvin K. W. Chan Jonathan C. Irish Natalie Coburn Julie Hallet Simron Singh Ambica Parmar Craig C. Earle Lauren Lapointe‐Shaw Monika K. Krzyzanowska Alexander V. Louie Alyson Mahar David R. Urbach Daniel I. McIsaac Danny Enepekides David Gomez Nicole J. Look Hong Jill Tinmouth Antoine Eskander Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort study Cancer Medicine cancer cancer detection cancer survivorship COVID‐19 oncology |
| title | Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort study |
| title_full | Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort study |
| title_fullStr | Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort study |
| title_full_unstemmed | Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort study |
| title_short | Early survival for patients newly diagnosed with cancer during COVID‐19 in Ontario, Canada: A population‐based cohort study |
| title_sort | early survival for patients newly diagnosed with cancer during covid 19 in ontario canada a population based cohort study |
| topic | cancer cancer detection cancer survivorship COVID‐19 oncology |
| url | https://doi.org/10.1002/cam4.5861 |
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