Mechanistic insights into the role of calcium in the allosteric regulation of the calmodulin-regulated death-associated protein kinase

Mechanistic insights into the role of calcium in the allosteric regulation of the calmodulin-regulated death-associated protein kinase

Calcium (Ca2+) signaling plays an important role in the regulation of many cellular functions. Ca2+-binding protein calmodulin (CaM) serves as a primary effector of calcium function. Ca2+/CaM binds to the death-associated protein kinase 1 (DAPK1) to regulate intracellular signaling pathways. However...

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Bibliographic Details
Main Authors: Xiaolong Li, Bo Li, Jun Li, Mingyuan Yang, Yushu Bai, Kai Chen, Ziqiang Chen, Ningfang Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
calcium
calmodulin
death-associated protein kinase
allostery
molecular dynamics simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1104942/full

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