A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia
Hayat Mushcab,1 Jaffar A Al-Tawfiq,2– 4 Mohammed Ghamdi,5 Amani Babgi,6 Abdulrazack Amir,7 Salwa S Sheikh,8 Adel Darwisheh,9 Abrar Alobaid,9 Arulanantham Zechariah Jebakumar,10 Saeed Qahtani,11 Ahmed Al Sagheir1 1Research Office, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arab...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-08-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/a-cohort-study-of-seroprevalence-of-antibodies-against-sars-cov-2-infe-peer-reviewed-fulltext-article-IDR |
| _version_ | 1811339192309907456 |
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| author | Mushcab H Al-Tawfiq JA Ghamdi M Babgi A Amir A Sheikh SS Darwisheh A Alobaid A Jebakumar AZ Qahtani S Al Sagheir A |
| author_facet | Mushcab H Al-Tawfiq JA Ghamdi M Babgi A Amir A Sheikh SS Darwisheh A Alobaid A Jebakumar AZ Qahtani S Al Sagheir A |
| author_sort | Mushcab H |
| collection | DOAJ |
| description | Hayat Mushcab,1 Jaffar A Al-Tawfiq,2– 4 Mohammed Ghamdi,5 Amani Babgi,6 Abdulrazack Amir,7 Salwa S Sheikh,8 Adel Darwisheh,9 Abrar Alobaid,9 Arulanantham Zechariah Jebakumar,10 Saeed Qahtani,11 Ahmed Al Sagheir1 1Research Office, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 2Infectious Disease Unit – Specialty Internal Medicine, and Quality and Patient Safety Department, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 3Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; 4Infectious Disease Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 5Population Health Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; 6Clinical Practice Education & Research, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 7Office of Academic Affairs, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 8Pathology Department, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 9Laboratory Services Department, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 10Vice Deanship of Postgraduate Studies Research, Prince Sultan Military College of Health Sciences, Dhahran, Eastern Province, Saudi Arabia; 11Wellness Institute, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi ArabiaCorrespondence: Hayat Mushcab, Research Office, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Eastern Province, Saudi Arabia, Tel +966540066447, Email hayat.almushcab@jhah.comBackground: The nature of the healthcare workers’ jobs standing at the frontline against the coronavirus disease 2019 (COVID-19) puts them at a higher risk of unknowingly contracting the disease and potentially contributing to the spread. This study aims to assess the overall positive seroconversion prevalence of SARS-CoV-2.Methods: This is a longitudinal cohort study of healthcare workers at Johns Hopkins Aramco Healthcare (JHAH). JHAH is a tertiary hospital located in Dhahran serving patients in several districts in the Eastern Province of Saudi Arabia. Participants were recruited between June and December 2020. Each participant had a serology blood test and completed the World Health Organization’s risk factor assessment questionnaire.Results: This study included 682 participants working in JHAH, representing 15.7% of our population. Out of the 682 participants, 15.2% had a positive SARS-CoV-2 rt-PCR before taking part in the study. However, only 87 tested positive for SARS-CoV-2 antibodies, a prevalence of 12.7% of all participants. Out of the 87 positives for SARS-CoV-2 antibodies, 17 participants never tested positive for COVID-19 rt-PCR, a prevalence of 2.9%. Moreover, not properly using alcohol-based hand rub or soap and water after the risk of body fluid exposure and wearing personal protective equipment when indicated were found to be statistically significant to having a positive SARS-CoV-2 IgG assay.Conclusion: Positive seroconversion rate was considerably low during the first wave of COVID-19 amongst JHAH’s healthcare workers and similar to other healthcare organizations in Saudi Arabia. Seropositivity correlated significantly with following infection prevention and control recommendations.Clinicaltrials.gov Identifier: NCT04469647.Keywords: COVID-19, coronavirus disease-2019, HCW, healthcare workers, prevalence, SARS-CoV-2 |
| first_indexed | 2024-04-13T18:21:42Z |
| format | Article |
| id | doaj.art-88d3d85b1383488798e03500dedf3efb |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-13T18:21:42Z |
| publishDate | 2022-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-88d3d85b1383488798e03500dedf3efb2022-12-22T02:35:24ZengDove Medical PressInfection and Drug Resistance1178-69732022-08-01Volume 154393440677264A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi ArabiaMushcab HAl-Tawfiq JAGhamdi MBabgi AAmir ASheikh SSDarwisheh AAlobaid AJebakumar AZQahtani SAl Sagheir AHayat Mushcab,1 Jaffar A Al-Tawfiq,2– 4 Mohammed Ghamdi,5 Amani Babgi,6 Abdulrazack Amir,7 Salwa S Sheikh,8 Adel Darwisheh,9 Abrar Alobaid,9 Arulanantham Zechariah Jebakumar,10 Saeed Qahtani,11 Ahmed Al Sagheir1 1Research Office, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 2Infectious Disease Unit – Specialty Internal Medicine, and Quality and Patient Safety Department, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 3Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; 4Infectious Disease Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 5Population Health Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; 6Clinical Practice Education & Research, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 7Office of Academic Affairs, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 8Pathology Department, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 9Laboratory Services Department, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia; 10Vice Deanship of Postgraduate Studies Research, Prince Sultan Military College of Health Sciences, Dhahran, Eastern Province, Saudi Arabia; 11Wellness Institute, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi ArabiaCorrespondence: Hayat Mushcab, Research Office, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Eastern Province, Saudi Arabia, Tel +966540066447, Email hayat.almushcab@jhah.comBackground: The nature of the healthcare workers’ jobs standing at the frontline against the coronavirus disease 2019 (COVID-19) puts them at a higher risk of unknowingly contracting the disease and potentially contributing to the spread. This study aims to assess the overall positive seroconversion prevalence of SARS-CoV-2.Methods: This is a longitudinal cohort study of healthcare workers at Johns Hopkins Aramco Healthcare (JHAH). JHAH is a tertiary hospital located in Dhahran serving patients in several districts in the Eastern Province of Saudi Arabia. Participants were recruited between June and December 2020. Each participant had a serology blood test and completed the World Health Organization’s risk factor assessment questionnaire.Results: This study included 682 participants working in JHAH, representing 15.7% of our population. Out of the 682 participants, 15.2% had a positive SARS-CoV-2 rt-PCR before taking part in the study. However, only 87 tested positive for SARS-CoV-2 antibodies, a prevalence of 12.7% of all participants. Out of the 87 positives for SARS-CoV-2 antibodies, 17 participants never tested positive for COVID-19 rt-PCR, a prevalence of 2.9%. Moreover, not properly using alcohol-based hand rub or soap and water after the risk of body fluid exposure and wearing personal protective equipment when indicated were found to be statistically significant to having a positive SARS-CoV-2 IgG assay.Conclusion: Positive seroconversion rate was considerably low during the first wave of COVID-19 amongst JHAH’s healthcare workers and similar to other healthcare organizations in Saudi Arabia. Seropositivity correlated significantly with following infection prevention and control recommendations.Clinicaltrials.gov Identifier: NCT04469647.Keywords: COVID-19, coronavirus disease-2019, HCW, healthcare workers, prevalence, SARS-CoV-2https://www.dovepress.com/a-cohort-study-of-seroprevalence-of-antibodies-against-sars-cov-2-infe-peer-reviewed-fulltext-article-IDRcovid-19coronavirus disease -2019hcwhealthcare workersprevalencesars-cov-2 |
| spellingShingle | Mushcab H Al-Tawfiq JA Ghamdi M Babgi A Amir A Sheikh SS Darwisheh A Alobaid A Jebakumar AZ Qahtani S Al Sagheir A A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia Infection and Drug Resistance covid-19 coronavirus disease -2019 hcw healthcare workers prevalence sars-cov-2 |
| title | A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia |
| title_full | A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia |
| title_fullStr | A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia |
| title_full_unstemmed | A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia |
| title_short | A Cohort Study of Seroprevalence of Antibodies Against SARS-CoV-2 Infection Among Healthcare Workers at a Tertiary Hospital in Saudi Arabia |
| title_sort | cohort study of seroprevalence of antibodies against sars cov 2 infection among healthcare workers at a tertiary hospital in saudi arabia |
| topic | covid-19 coronavirus disease -2019 hcw healthcare workers prevalence sars-cov-2 |
| url | https://www.dovepress.com/a-cohort-study-of-seroprevalence-of-antibodies-against-sars-cov-2-infe-peer-reviewed-fulltext-article-IDR |
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