Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis
Plant natural products (PNPs) have shown various pharmaceutical activities, possessing great potential in global markets. Microbial cell factories (MCFs) provide an economical and sustainable alternative for the synthesis of valuable PNPs compared with traditional approaches. However, the heterologo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/6/633 |
| _version_ | 1827738261147090944 |
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| author | Jianli Zhang Xinyu Gong Qi Gan Yajun Yan |
| author_facet | Jianli Zhang Xinyu Gong Qi Gan Yajun Yan |
| author_sort | Jianli Zhang |
| collection | DOAJ |
| description | Plant natural products (PNPs) have shown various pharmaceutical activities, possessing great potential in global markets. Microbial cell factories (MCFs) provide an economical and sustainable alternative for the synthesis of valuable PNPs compared with traditional approaches. However, the heterologous synthetic pathways always lack native regulatory systems, bringing extra burden to PNPs production. To overcome the challenges, biosensors have been exploited and engineered as powerful tools for establishing artificial regulatory networks to control enzyme expression in response to environments. Here, we reviewed the recent progress involved in the application of biosensors that are responsive to PNPs and their precursors. Specifically, the key roles these biosensors played in PNP synthesis pathways, including isoprenoids, flavonoids, stilbenoids and alkaloids, were discussed in detail. |
| first_indexed | 2024-03-11T02:41:55Z |
| format | Article |
| id | doaj.art-88d3ef2c9885449ba29775c244bc1d9a |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T02:41:55Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-88d3ef2c9885449ba29775c244bc1d9a2023-11-18T09:32:59ZengMDPI AGBiosensors2079-63742023-06-0113663310.3390/bios13060633Application of Metabolite-Responsive Biosensors for Plant Natural Products BiosynthesisJianli Zhang0Xinyu Gong1Qi Gan2Yajun Yan3School of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USASchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USASchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USASchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, The University of Georgia, Athens, GA 30602, USAPlant natural products (PNPs) have shown various pharmaceutical activities, possessing great potential in global markets. Microbial cell factories (MCFs) provide an economical and sustainable alternative for the synthesis of valuable PNPs compared with traditional approaches. However, the heterologous synthetic pathways always lack native regulatory systems, bringing extra burden to PNPs production. To overcome the challenges, biosensors have been exploited and engineered as powerful tools for establishing artificial regulatory networks to control enzyme expression in response to environments. Here, we reviewed the recent progress involved in the application of biosensors that are responsive to PNPs and their precursors. Specifically, the key roles these biosensors played in PNP synthesis pathways, including isoprenoids, flavonoids, stilbenoids and alkaloids, were discussed in detail.https://www.mdpi.com/2079-6374/13/6/633plant natural productsbiosensormetabolic engineering |
| spellingShingle | Jianli Zhang Xinyu Gong Qi Gan Yajun Yan Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis Biosensors plant natural products biosensor metabolic engineering |
| title | Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis |
| title_full | Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis |
| title_fullStr | Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis |
| title_full_unstemmed | Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis |
| title_short | Application of Metabolite-Responsive Biosensors for Plant Natural Products Biosynthesis |
| title_sort | application of metabolite responsive biosensors for plant natural products biosynthesis |
| topic | plant natural products biosensor metabolic engineering |
| url | https://www.mdpi.com/2079-6374/13/6/633 |
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