Olfactory neuroblastoma: diagnosis, management, and current treatment options
Olfactory neuroblastoma (ONB) is a rare neoplasm originating from the olfactory neuroepithelium representing 3-6% of tumors of the sinonasal tract. ONB require multi-disciplinary care. Historically, the gold standard surgical procedure for ONB has been open craniofacial resection. In the last years,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1242453/full |
| _version_ | 1797659519732416512 |
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| author | Alicia Tosoni Vincenzo Di Nunno Lidia Gatto Giacomo Corradi Stefania Bartolini Lucia Ranieri Enrico Franceschi |
| author_facet | Alicia Tosoni Vincenzo Di Nunno Lidia Gatto Giacomo Corradi Stefania Bartolini Lucia Ranieri Enrico Franceschi |
| author_sort | Alicia Tosoni |
| collection | DOAJ |
| description | Olfactory neuroblastoma (ONB) is a rare neoplasm originating from the olfactory neuroepithelium representing 3-6% of tumors of the sinonasal tract. ONB require multi-disciplinary care. Historically, the gold standard surgical procedure for ONB has been open craniofacial resection. In the last years, endoscopic endonasal approaches have been largely introduced with lower complication rates, shorter hospital stay, and similar clinical outcome. Radiotherapy plays an important role in the management of ONB, however there are not generally accepted recommendations for its application. Although there is agreement that multimodal therapy is needed, the optimal use of chemotherapy is still unknown. The rarity of the disease, makes difficult to draw definitive conclusions about the role of systemic treatment in induction and concomitant setting. |
| first_indexed | 2024-03-11T18:16:18Z |
| format | Article |
| id | doaj.art-88d6adfab2f84a68b65cd2b4d3029f5b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T18:16:18Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-88d6adfab2f84a68b65cd2b4d3029f5b2023-10-16T07:12:08ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-10-011310.3389/fonc.2023.12424531242453Olfactory neuroblastoma: diagnosis, management, and current treatment optionsAlicia Tosoni0Vincenzo Di Nunno1Lidia Gatto2Giacomo Corradi3Stefania Bartolini4Lucia Ranieri5Enrico Franceschi6Nervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyNervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyDepartment of Oncology, Azienda Unità Sanitaria Locale (AUSL) Bologna, Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, ItalyNervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyNervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyNervous System Medical Oncology Department, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, ItalyOlfactory neuroblastoma (ONB) is a rare neoplasm originating from the olfactory neuroepithelium representing 3-6% of tumors of the sinonasal tract. ONB require multi-disciplinary care. Historically, the gold standard surgical procedure for ONB has been open craniofacial resection. In the last years, endoscopic endonasal approaches have been largely introduced with lower complication rates, shorter hospital stay, and similar clinical outcome. Radiotherapy plays an important role in the management of ONB, however there are not generally accepted recommendations for its application. Although there is agreement that multimodal therapy is needed, the optimal use of chemotherapy is still unknown. The rarity of the disease, makes difficult to draw definitive conclusions about the role of systemic treatment in induction and concomitant setting.https://www.frontiersin.org/articles/10.3389/fonc.2023.1242453/fullesthesioneuroblastomaolfactory neuroblastomachemotherapyradiotherapysurgery |
| spellingShingle | Alicia Tosoni Vincenzo Di Nunno Lidia Gatto Giacomo Corradi Stefania Bartolini Lucia Ranieri Enrico Franceschi Olfactory neuroblastoma: diagnosis, management, and current treatment options Frontiers in Oncology esthesioneuroblastoma olfactory neuroblastoma chemotherapy radiotherapy surgery |
| title | Olfactory neuroblastoma: diagnosis, management, and current treatment options |
| title_full | Olfactory neuroblastoma: diagnosis, management, and current treatment options |
| title_fullStr | Olfactory neuroblastoma: diagnosis, management, and current treatment options |
| title_full_unstemmed | Olfactory neuroblastoma: diagnosis, management, and current treatment options |
| title_short | Olfactory neuroblastoma: diagnosis, management, and current treatment options |
| title_sort | olfactory neuroblastoma diagnosis management and current treatment options |
| topic | esthesioneuroblastoma olfactory neuroblastoma chemotherapy radiotherapy surgery |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1242453/full |
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