Parkin is protective against proteotoxic stress in a transgenic zebrafish model.

Mutations in the gene encoding the E3 ubiquitin ligase parkin (PARK2) are responsible for the majority of autosomal recessive parkinsonism. Similarly to other knockout mouse models of PD-associated genes, parkin knockout mice do not show a substantial neuropathological or behavioral phenotype, while...

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Bibliographic Details
Main Authors: Mareike E Fett, Anna Pilsl, Dominik Paquet, Frauke van Bebber, Christian Haass, Jörg Tatzelt, Bettina Schmid, Konstanze F Winklhofer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-07-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2912770?pdf=render