The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results
Objective: The aim of this study was to investigate the performance of functional neuro-imaging for describe neurological involvement in Lupus Erithematosus Systemicus. Methods. 20 SLE patients were included into this study (18 females / 2 males). Median age was 40.5 years (range 16 –66 ys), 9 patie...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2004-03-01
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| Series: | Reumatismo |
| Online Access: | https://reumatismo.org/index.php/reuma/article/view/145 |
| _version_ | 1811291148112625664 |
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| author | M. Padovan A. Locaputo N. Rizzo M. Govoni F. Trotta |
| author_facet | M. Padovan A. Locaputo N. Rizzo M. Govoni F. Trotta |
| author_sort | M. Padovan |
| collection | DOAJ |
| description | Objective: The aim of this study was to investigate the performance of functional neuro-imaging for describe neurological involvement in Lupus Erithematosus Systemicus. Methods. 20 SLE patients were included into this study (18 females / 2 males). Median age was 40.5 years (range 16 –66 ys), 9 patients with a clear neurological involvement, 7 with aspecific neurological symptoms and 4 were asymptomatics, according to 1999 ACR Classification. All patients were underwent to conventional resonance imaging (RMFLAIR), RM perfusion ( RM-PWI), RM diffusion (RM-DWI) and cerebral SPECT. The RM techniques was performed using a 1 Tesla “Signa-Horizon” Tomograph by General Eletric: The data analysis was performed from two indipendent neuroradiologist and than trough coordinated evalutation after coregistration of acquired volumes. Results: In 11/20 patients (55%) lesions were demonstrated in RM-FLAIR evaluation, more frequent in cases with focal symptoms than in diffuse. RM-PWI was positive in 50% of cases. SPECT analysis was altered in 85 % of patients. In all patients RM-DWI evaluation was negative. 5 of 29 lesional areas (3 patients) showed by SPECT analysis were positive in RM-PWI. None of them was positive in RM-FLAIR study. After coordinated evaluation of RM-FLAIR, SPECT and RM-PWI, 7 findings were considered false positive. 6 Of patients with negative RM-FLAIR were positive in SPECT and 3 in RM-PWI. Only 1 patient was positive in SPECT and RM-PWI. Conclusions: According to the literature, the RM-FLAIR is a very sensitive procedure to describe the lesional charge, especially in patients with focal symptoms. All lesions was considered as stable outcomes due to negativity of RM-DWI analysis. The SPECT is a sensitive technique to individuate cerebral areas of altered perfusion. The coregistration seems to be an helpful method to improve the explanation of uncertain cases. e the sections are prepared for the microscopic analysis of the various histomorphometric parameters. |
| first_indexed | 2024-04-13T04:24:04Z |
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| id | doaj.art-88d7ff30c8e54bffa4ad42af19453ec2 |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-04-13T04:24:04Z |
| publishDate | 2004-03-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-88d7ff30c8e54bffa4ad42af19453ec22022-12-22T03:02:36ZengPAGEPress PublicationsReumatismo0048-74492240-26832004-03-0156110.4081/reumatismo.2004.24The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary resultsM. PadovanA. LocaputoN. RizzoM. GovoniF. TrottaObjective: The aim of this study was to investigate the performance of functional neuro-imaging for describe neurological involvement in Lupus Erithematosus Systemicus. Methods. 20 SLE patients were included into this study (18 females / 2 males). Median age was 40.5 years (range 16 –66 ys), 9 patients with a clear neurological involvement, 7 with aspecific neurological symptoms and 4 were asymptomatics, according to 1999 ACR Classification. All patients were underwent to conventional resonance imaging (RMFLAIR), RM perfusion ( RM-PWI), RM diffusion (RM-DWI) and cerebral SPECT. The RM techniques was performed using a 1 Tesla “Signa-Horizon” Tomograph by General Eletric: The data analysis was performed from two indipendent neuroradiologist and than trough coordinated evalutation after coregistration of acquired volumes. Results: In 11/20 patients (55%) lesions were demonstrated in RM-FLAIR evaluation, more frequent in cases with focal symptoms than in diffuse. RM-PWI was positive in 50% of cases. SPECT analysis was altered in 85 % of patients. In all patients RM-DWI evaluation was negative. 5 of 29 lesional areas (3 patients) showed by SPECT analysis were positive in RM-PWI. None of them was positive in RM-FLAIR study. After coordinated evaluation of RM-FLAIR, SPECT and RM-PWI, 7 findings were considered false positive. 6 Of patients with negative RM-FLAIR were positive in SPECT and 3 in RM-PWI. Only 1 patient was positive in SPECT and RM-PWI. Conclusions: According to the literature, the RM-FLAIR is a very sensitive procedure to describe the lesional charge, especially in patients with focal symptoms. All lesions was considered as stable outcomes due to negativity of RM-DWI analysis. The SPECT is a sensitive technique to individuate cerebral areas of altered perfusion. The coregistration seems to be an helpful method to improve the explanation of uncertain cases. e the sections are prepared for the microscopic analysis of the various histomorphometric parameters.https://reumatismo.org/index.php/reuma/article/view/145 |
| spellingShingle | M. Padovan A. Locaputo N. Rizzo M. Govoni F. Trotta The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results Reumatismo |
| title | The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results |
| title_full | The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results |
| title_fullStr | The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results |
| title_full_unstemmed | The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results |
| title_short | The evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging. Preliminary results |
| title_sort | evaluation of neuropsychiatric lupus erythematosus by functional neuroimaging preliminary results |
| url | https://reumatismo.org/index.php/reuma/article/view/145 |
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