Immunouniverse of SARS-CoV-2
AbstractSARS-CoV-2 virus has become a global health problem that has caused millions of deaths worldwide. The infection can present with multiple clinical features ranging from asymptomatic or mildly symptomatic patients to patients with severe or critical illness that can even lead to death. Althou...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-10-01
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| Series: | Immunological Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2022.2066251 |
| _version_ | 1797272362861723648 |
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| author | Dennis Jiménez Marbel Torres Arias |
| author_facet | Dennis Jiménez Marbel Torres Arias |
| author_sort | Dennis Jiménez |
| collection | DOAJ |
| description | AbstractSARS-CoV-2 virus has become a global health problem that has caused millions of deaths worldwide. The infection can present with multiple clinical features ranging from asymptomatic or mildly symptomatic patients to patients with severe or critical illness that can even lead to death. Although the immune system plays an important role in pathogen control, SARS-CoV-2 can drive dysregulation of this response and trigger severe immunopathology. Exploring the mechanisms of the immune response involved in host defense against SARS-CoV-2 allows us to understand its immunopathogenesis and possibly detect features that can be used as potential therapies to eliminate the virus. The main objective of this review on SARS-CoV-2 is to highlight the interaction between the virus and the immune response. We explore the function and action of the immune system, the expression of molecules at the site of infection that cause hyperinflammation and hypercoagulation disorders, the factors leading to the development of pneumonia and subsequent severe acute respiratory distress syndrome which is the leading cause of death in patients with COVID-19. |
| first_indexed | 2024-03-07T14:27:14Z |
| format | Article |
| id | doaj.art-88d8b0aadb8041949e8ef906475dfb57 |
| institution | Directory Open Access Journal |
| issn | 2578-5826 |
| language | English |
| last_indexed | 2024-03-07T14:27:14Z |
| publishDate | 2022-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj.art-88d8b0aadb8041949e8ef906475dfb572024-03-06T06:50:16ZengTaylor & Francis GroupImmunological Medicine2578-58262022-10-0145418622410.1080/25785826.2022.2066251Immunouniverse of SARS-CoV-2Dennis Jiménez0Marbel Torres Arias1Departamento de Ciencias de la Vida y Agricultura, Carrera de Ingeniería en Biotecnología, Universidad de las Fuerzas Armadas ESPE, Sangolquí, Pichincha, EcuadorDepartamento de Ciencias de la Vida y Agricultura, Carrera de Ingeniería en Biotecnología, Universidad de las Fuerzas Armadas ESPE, Sangolquí, Pichincha, EcuadorAbstractSARS-CoV-2 virus has become a global health problem that has caused millions of deaths worldwide. The infection can present with multiple clinical features ranging from asymptomatic or mildly symptomatic patients to patients with severe or critical illness that can even lead to death. Although the immune system plays an important role in pathogen control, SARS-CoV-2 can drive dysregulation of this response and trigger severe immunopathology. Exploring the mechanisms of the immune response involved in host defense against SARS-CoV-2 allows us to understand its immunopathogenesis and possibly detect features that can be used as potential therapies to eliminate the virus. The main objective of this review on SARS-CoV-2 is to highlight the interaction between the virus and the immune response. We explore the function and action of the immune system, the expression of molecules at the site of infection that cause hyperinflammation and hypercoagulation disorders, the factors leading to the development of pneumonia and subsequent severe acute respiratory distress syndrome which is the leading cause of death in patients with COVID-19.https://www.tandfonline.com/doi/10.1080/25785826.2022.2066251Hyperinflammationhypercoagulationcytokinesimmune response |
| spellingShingle | Dennis Jiménez Marbel Torres Arias Immunouniverse of SARS-CoV-2 Immunological Medicine Hyperinflammation hypercoagulation cytokines immune response |
| title | Immunouniverse of SARS-CoV-2 |
| title_full | Immunouniverse of SARS-CoV-2 |
| title_fullStr | Immunouniverse of SARS-CoV-2 |
| title_full_unstemmed | Immunouniverse of SARS-CoV-2 |
| title_short | Immunouniverse of SARS-CoV-2 |
| title_sort | immunouniverse of sars cov 2 |
| topic | Hyperinflammation hypercoagulation cytokines immune response |
| url | https://www.tandfonline.com/doi/10.1080/25785826.2022.2066251 |
| work_keys_str_mv | AT dennisjimenez immunouniverseofsarscov2 AT marbeltorresarias immunouniverseofsarscov2 |